stm
Chemically induced Allele Detail

Summary

• Symbol: stm
• Name: stumpy
• MGI ID: MGI:1857057
• Gene: stm Location: unknown
• Alliance: stm page

Mutation origin

• Strain of Origin: CBA/FaCam

Mutation description

• Allele Type: Chemically induced (other)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any stm Mutation: 1 strain or line available

Notes

This steroid-induced mutation arose in an experiment testing the mutagenicity of contraceptive steroids. Viability and fertility are both reasonably good. Affected animals are recognizable at birth or a few days afterwards (J:13626). All cartilage bones, as well as the secondary cartilage of the mandibular condyle (J:7341), are affected to a greater or lesser degree. They are usually shortened, and may have widened areas of muscle attachment. The proximal long bones are more severely affected than the distal long bones (J:5970). In cartilage of the epiphyseal plates there is an abnormally wide zone of hypertrophy, a slightly increased mitotic rate, and more chondrocytes per lacuna than normal. Electron microscopy shows many chondrocytes to be in close apposition, some with tight junctions, and there is much interdigitation and interfolding of the cell membranes of adjacent chondrocytes (J:5848). Growth of the femur and tibia is fairly rapid at first but stops in the 16- to 21-day period (J:5934). The main factor responsible for reduced growth of the bones is low height of the cells of the hypertrophic layer (J:7065).

References

• Original: J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
• All: 6 reference(s)