Utp14b^jsd
Spontaneous Allele Detail

Summary

• Symbol: Utp14b^jsd
• Name: UTP14B small subunit processome component; juvenile spermatogonial depletion
• MGI ID: MGI:1856924
• Synonyms: jsd
• Gene: Utp14b Location: Chr1:78635600-78645305 bp, + strand Genetic Position: Chr1, 40.84 cM
• Alliance: Utp14b^jsd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: A CC to GAAAAG substitution 304 bp from the ATG putatively results in a frame shift such that after the first 105 amino acids, there are two substitutions (GE to LF) followed by a stop codon. (J:91782)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Utp14b Mutation: 34 strains or lines available

Notes

Homozygous females are normal and fertile. Homozygous males have small testes, normal serum testosterone, elevated serum follicle-stimulating hormone, azoospermia, and normal body and seminal vesicle weights. At 3 to 4 weeks, there is a reduction in number of spermatogenic cells that proceeds at different rates in different tubules, but by 8 to 10 weeks most tubules are devoid of germ cells, leaving only Sertoli cells(J:9278).

References

• Original: J:35669 Beamer WG, et al., Juvenile spermatogonal depletion (jsd). Mouse News Lett. 1984;70:84
• All: 27 reference(s)