Socs2^hg
Spontaneous Allele Detail

Summary

• Symbol: Socs2^hg
• Name: suppressor of cytokine signaling 2; high growth
• MGI ID: MGI:1856899
• Synonyms: Cish2^hg, hg
• Gene: Socs2 Location: Chr10:95221224-95253042 bp, - strand Genetic Position: Chr10, 49.35 cM
• Alliance: Socs2^hg page

Mutation origin

• Strain of Origin: AKR/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Deletion
• Socs2^hg involves 4 genes/genome features (Plxnc1, Cradd, 2310039L15Rik ...) View all
• Mutation details: The high growth mutation is a spontaneous deletion of 486,178 bp on Chr 10 with breakpoints in the second introns of suppressor of cytokine signaling 2 (Socs2) and plexin C1 (Plxnc1). It entirely eliminates Cradd (CASP2 and RIPK1 domain containing adaptor with death domain)/Raidd and results in generation of an 8.5 kb fusion transcript that joins the first two exons of Socs2 to the third exon of Plxnc1, which contains at least 20 exons. Of tissues analyzed, this fusion mRNA exhibits the highest expression in brain and much lower expression in liver and heart. (J:68342, J:80771)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

25 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs2 Mutation: 23 strains or lines available

Notes

Discovered at generation 25 in a stock derived from a four-way cross of AKR/J, C3H/HeJ, C57BL/6J and DBA/2J.

References

• Original: J:220666 Bradford GE, Growth and reproduction in mice selected for rapid body weight gain. Genetics. 1971 Dec;69(4):499-512
• All: 22 reference(s)