Rab38^cht
Spontaneous Allele Detail

Summary

• Symbol: Rab38^cht
• Name: RAB38, member RAS oncogene family; chocolate
• MGI ID: MGI:1856819
• Synonyms: chocolate, cht
• Gene: Rab38 Location: Chr7:88079481-88140780 bp, + strand Genetic Position: Chr7, 49.19 cM
• Alliance: Rab38^cht page

Brown coat color in Rab38^cht/Rab38^cht mice (right)

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-T transversion mutation at coding nucleotide 56 (c.56G>T) in exon 1 results in a glycine to valine substitution in codon 19 of the gene (p.G19V). This mutation lies within the highly conserved phosphate/Mg²⁺ domain. (J:75774)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab38 Mutation: 15 strains or lines available

Notes

This allele has been maintained on the C57BL/6J background at The Jackson Laboratory since 1984 when it was first identified.

References

• Original: J:13967 MacPike A, et al., New coat color mutations, Dbr and cht. Mouse News Lett. 1984;70:86
• All: 12 reference(s)