Qki^qk-l1
Chemically induced Allele Detail

Summary

• Symbol: Qki^qk-l1
• Name: quaking, KH domain containing RNA binding; quaking lethal 1
• MGI ID: MGI:1856538
• Synonyms: l(17)Wi, qk^l-1, Qk^l17Wis1
• Gene: Qki Location: Chr17:10425480-10538706 bp, - strand Genetic Position: Chr17, 7.75 cM
• Alliance: Qki^qk-l1 page

Growth retardation and impaired vascular development in Qki^qk-l1/Qki^qk-l1 and Qki^qk-k2/Qki^qk-k2 embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BTBR

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation underlying the phenotype of the Qk^l-1 mouse has been attributed to an A to G transition at nucleotide 2783, resulting in loss of protein isoform QKI-5. (J:55007)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qki Mutation: 26 strains or lines available

Notes

A number of lethal mutations were induced in the t region of Chr 17 using ENU. One such mutation, labeled l(17)1Wi, was found to survive in heterozygous state with the classic Qk mutant (which the authors refer to as qk^v to emphasize its viability). The l¹⁷ symbol was then changed to qk^l-1 (J:9032).

References

• Original: J:8293 Shedlovsky A, et al., Induction of recessive lethal mutations in the T/t-H-2 region of the mouse genome by a point mutagen. Genet Res. 1986 Apr;47(2):135-42
• All: 4 reference(s)