Mgrn1^md
Spontaneous Allele Detail

Summary

• Symbol: Mgrn1^md
• Name: mahogunin, ring finger 1; mahoganoid
• MGI ID: MGI:1856070
• Synonyms: md
• Gene: Mgrn1 Location: Chr16:4704113-4756160 bp, + strand Genetic Position: Chr16, 2.48 cM, cytoband A1
• Alliance: Mgrn1^md page

Mgrn1^md/+ and Mgrn1^md/Mgrn1^md

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

Allele Type: Spontaneous Mutation: Transposon insertion Mutation details: The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. (J:80182) Inheritance: Recessive

Schematic of the location of the IAP insertion generating the Mgrn1^md allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Mgrn1 Mutation: 54 strains or lines available

Notes

The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrn^mg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).

References

• Original: J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
• All: 9 reference(s)