Tyr^c-m
Radiation induced Allele Detail

Summary

• Symbol: Tyr^c-m
• Name: tyrosinase; chinchilla mottled
• MGI ID: MGI:1855980
• Synonyms: c^22H, chinchilla mottled, c^m
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-m page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Other
• Mutation details: Coding regions of the Tyr^c-m gene are normal, but there is a rearrangement of 5'-upstream regulatory sequences including the locus control region of the Tyr gene. Low-level transcription of tyrosinase and reduced sensitivity to DNAase I was found in clones from light pigmenting melanocytes of homozygotes, while in clones from dark pigmenting cells, tyrosinase transcription was higher (though still less than wild-type) and DNAase sensitivity greater. The upstream rearrangement may separate the Tyr structural gene from cis-acting control elements. (J:997, J:105054)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 375 strains or lines available

Notes

This mutation was found in the progeny of a neutron-irradiated male at Harwell. Homozygotes and Tyr^c-m/Tyr^c-ch heterozygotes have patches of chinchilla-type fur and patches of lighter fur similar to that of Tyr^c/Tyr^c-ch heterozygotes. The two genotypes are distinguishable by the whiter belly of Tyr^c-m homozygous mice (J:13502). Coding regions of the Tyr^c-m gene are normal, but upstream sequences are rearranged. Low-level transcription of tyrosinase and reduced sensitivity to DNAase I was found in clones from light pigmenting melanocytes of homozygotes, while in clones from dark pigmenting cells, tyrosinase transcription was higher (though still less than wild-type) and DNAase sensitivity greater. The upstream rearrangement may separate the Tyr structural gene from cis-acting control elements, and the resulting variability of expression cause the light and dark fur patches (J:997). The triple homozygote Tyr^c-m/Tyr^c-m Mchm1/Mchm1 Mchm2/Mchm2 is essentially a black-eyed white mouse (J:13834).

References

• Original: J:13502 Phillips RJS, Chinchilla-mottled. Mouse News Lett. 1970;42:26
• All: 5 reference(s)