About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:348278 Liakath-Ali K, et al., Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development. PLoS Biol. 2024 May;22(5):e3002599
Assay type: RNA in situ
MGI Accession ID: MGI:8259045
Gene symbol: Tenm4
Gene name: teneurin transmembrane protein 4
Probe: Mm-Tenm4 (555491)
Probe preparation: Antisense DNA
Visualized with: Fluorescence
Results
Specimen 2A: embryonic day 16.5 (more )
Note: Data from bubble plots of expression level was included in the annotation. Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S2_Tenm3 4 Dapi row 2 , S2_Tenm3 4 row 2 , 2A Tenm4 , 2A Tenm3 4 , S2_Tenm4 row 2 Expression was detected in the cornu Ammonis and subiculum.
TS24: dentate gyrus Present S2_Tenm3 4 row 2 , S2_Tenm3 4 Dapi row 2 , 2A Tenm3 4 , 2A Tenm4 , S2_Tenm4 row 2
TS24: entorhinal cortex Present S2_Tenm3 4 row 2 , S2_Tenm3 4 Dapi row 2 , 2A Tenm3 4 , 2A Tenm4 , S2_Tenm4 row 2
Specimen 2B: postnatal day 0 (more )
Note: Data from bubble plots of expression level was included in the annotation. Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: dentate gyrus Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
TS27: entorhinal cortex Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
TS27: hippocampus CA1 Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
TS27: hippocampus CA2 Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
TS27: hippocampus CA3 Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
TS27: subiculum Strong S4_Tenm4 row 2 , 2B Tenm3 4 , S4_Tenm3 4 Dapi row 2 , S4_Tenm3 4 row 2 , 2B Tenm4
Specimen 2E: postnatal day 10 (more )
Note: Data from bubble plots of expression level was included in the annotation. Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampus stratum oriens Present 2E Tenm3 4 , 2E Tenm4 , S6_Tenm4 row 3 , S6_Tenm3 4 Dapi row 3 , S6_Tenm3 4 row 3
TS28: CA1 pyramidal cell layer Strong 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3 , 2E Tenm4 , S6_Tenm4 row 3 , S6_Tenm3 4 row 3
TS28: CA2 pyramidal cell layer Strong 2E Tenm4 , S6_Tenm4 row 3 , S6_Tenm3 4 Dapi row 3 , S6_Tenm3 4 row 3 , 2E Tenm3 4
TS28: CA3 pyramidal cell layer Strong S6_Tenm4 row 3 , 2E Tenm4 , 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3 , S6_Tenm3 4 row 3
TS28: hippocampus stratum radiatum Present S6_Tenm3 4 Dapi row 3 , S6_Tenm4 row 3 , S6_Tenm3 4 row 3 , 2E Tenm3 4 , 2E Tenm4
TS28: hippocampus stratum lacunosum Present S6_Tenm3 4 row 3 , S6_Tenm4 row 3 , 2E Tenm4 , 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3
TS28: dentate gyrus molecular layer Present S6_Tenm4 row 3 , S6_Tenm3 4 Dapi row 3 , 2E Tenm3 4 , S6_Tenm3 4 row 3 , 2E Tenm4
TS28: dentate gyrus granule cell layer Strong S6_Tenm3 4 row 3 , 2E Tenm4 , S6_Tenm4 row 3 , 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3
TS28: dentate gyrus polymorphic layer Present 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3 , 2E Tenm4 , S6_Tenm3 4 row 3 , S6_Tenm4 row 3
TS28: subiculum Present 2E Tenm3 4 , 2E Tenm4 , S6_Tenm3 4 row 3 , S6_Tenm4 row 3 , S6_Tenm3 4 Dapi row 3 Expression was detected in the presubiculum and subiculum.
TS28: entorhinal cortex Present Non-Uniform S6_Tenm3 4 row 3 , S6_Tenm4 row 3 , 2E Tenm4 , 2E Tenm3 4 , S6_Tenm3 4 Dapi row 3 Varying expression levels were detected in layers 1-6 of the entorhinal cortex.
Specimen 2F: postnatal day 30 (more )
Note: Data from bubble plots of expression level was included in the annotation. Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampus stratum oriens Present Non-Uniform S8_Tenm3 4 row 1 , S8_Tenm4 row 1 , 2F Tenm3 4 , S8_Tenm3 4 Dapi row 1 , 2F Tenm4
TS28: CA1 pyramidal cell layer Present S8_Tenm4 row 1 , 2F Tenm4 , S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1 , 2F Tenm3 4
TS28: CA2 pyramidal cell layer Present 2F Tenm3 4 , 2F Tenm4 , S8_Tenm4 row 1 , S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1
TS28: CA3 pyramidal cell layer Present S8_Tenm4 row 1 , 2F Tenm3 4 , 2F Tenm4 , S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1
TS28: hippocampus stratum radiatum Weak Regionally restricted S8_Tenm3 4 row 1 , 2F Tenm4 , S8_Tenm4 row 1 , S8_Tenm3 4 Dapi row 1 , 2F Tenm3 4 Weak expression was detected in the stratum radiatum of the CA2 region.
TS28: hippocampus stratum lacunosum Weak 2F Tenm3 4 , S8_Tenm4 row 1 , S8_Tenm3 4 row 1 , S8_Tenm3 4 Dapi row 1 , 2F Tenm4
TS28: dentate gyrus molecular layer Absent 2F Tenm4 , S8_Tenm3 4 row 1 , S8_Tenm3 4 Dapi row 1 , 2F Tenm3 4 , S8_Tenm4 row 1
TS28: dentate gyrus granule cell layer Present 2F Tenm3 4 , 2F Tenm4 , S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1 , S8_Tenm4 row 1
TS28: dentate gyrus polymorphic layer Present 2F Tenm3 4 , S8_Tenm4 row 1 , 2F Tenm4 , S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1
TS28: subiculum Present S8_Tenm3 4 Dapi row 1 , S8_Tenm3 4 row 1 , 2F Tenm3 4 , S8_Tenm4 row 1 , 2F Tenm4 Expression was detected in the presubiculum and subiculum.
TS28: entorhinal cortex Present Regionally restricted 2F Tenm3 4 , S8_Tenm4 row 1 , S8_Tenm3 4 Dapi row 1 , 2F Tenm4 , S8_Tenm3 4 row 1 Diminished expression was detected in layers 2-6 of the entorhinal cortex.
Specimen 3E P10: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: CA1 pyramidal cell layer Present S7_Tenm3 4 Dapi row 3 , S7_Tenm3 4 row 3 , 3E P10 red dotted 6 , 3E P10 left bottom , 3E P10 red dotted 5 , S7_Tenm4 row 3
TS28: entorhinal cortex Present Non-Uniform S7_Tenm3 4 Dapi row 3 , S7_Tenm4 row 3 , 3E P10 green dotted 5 , 3E P10 left bottom , 3E P10 green dotted 6 , S7_Tenm3 4 row 3 Expression level was higher in layers 5/6.
Specimen 3E P30: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: CA1 pyramidal cell layer Present 3E P30 left bottom , S9_Tenm4 row 4 , S9_Tenm3 4 row 4 , S9_Tenm3 4 Dapi row 4 , 3E P30 red dotted 6 , 3E P30 red dotted 5
TS28: entorhinal cortex Present Non-Uniform S9_Tenm3 4 row 4 , 3E P30 left bottom , 3E P30 green dotted 5 , S9_Tenm4 row 4 , S9_Tenm3 4 Dapi row 4 , 3E P30 green dotted 6 Expression level was higher in layers 5/6.
Specimen 7E: postnatal (more )
Note: Sections were post-fixed in 4% paraformaldehyde. Triple labeled: magenta - Tenm4; green - Adgrl1 (assay MGI:8259184); red - Adgrl2 (assay MGI:8259230).
Structure Cell Type Level Pattern Image Note
TS28: CA1 pyramidal cell layer hippocampal pyramidal neuron Present 7E' , 7E , 7E CA1 bottom Tenms and Lphns expression largely overlapped in CA1 stratum pyramidale cells and dentate gyrus granule cells, albeit with varying levels of expression.
TS28: dentate gyrus granule cell layer dentate gyrus granule cell Present 7E DG bottom , 7E , 7E'' Tenms and Lphns expression largely overlapped in CA1 stratum pyramidale cells and dentate gyrus granule cells, albeit with varying levels of expression.
TS28: dentate gyrus polymorphic layer Present Regionally restricted 7E'' , 7E , 7E DG bottom In the dentate gyrus polymorph layer, the excitatory hilar cells had overlapping expression between Lphn1 and Tenm4.
Specimen 7F: postnatal (more )
Note: Sections were post-fixed in 4% paraformaldehyde. Triple labeled: magenta - Tenm4; green - Adgrl1 (assay MGI:8259184); red - Adgrl3 (assay MGI:8259232).
Structure Cell Type Level Pattern Image Note
TS28: CA1 pyramidal cell layer hippocampal pyramidal neuron Present 7F' , 7F , 7F CA1 bottom Tenms and Lphns expression largely overlapped in CA1 stratum pyramidale cells and dentate gyrus granule cells, albeit with varying levels of expression.
TS28: dentate gyrus granule cell layer dentate gyrus granule cell Present 7F , 7F'' , 7F DG bottom Tenms and Lphns expression largely overlapped in CA1 stratum pyramidale cells and dentate gyrus granule cells, albeit with varying levels of expression.
TS28: dentate gyrus polymorphic layer Present Regionally restricted 7F DG bottom , 7F'' , 7F In the dentate gyrus polymorph layer, the excitatory hilar cells had overlapping expression between Lphn1 and Tenm4.
Specimen S2 row 1: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S2_Tenm4 row 1 , S2_Tenm3 4 Dapi row 1 , S2_Tenm3 4 row 1
Specimen S2 row 3: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S2_Tenm3 4 row 3 , S2_Tenm3 4 Dapi row 3 , S2_Tenm4 row 3
Specimen S2 row 4: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S2_Tenm4 row 4 , S2_Tenm3 4 row 4 , S2_Tenm3 4 Dapi row 4
Specimen S3 row 1: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S3_Tenm3 4 row 1 , S3_Tenm4 row 1 , S3_Tenm3 4 Dapi row 1
Specimen S3 row 2: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S3_Tenm3 4 Dapi row 2 , S3_Tenm3 4 row 2 , S3_Tenm4 row 2
Specimen S3 row 3: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S3_Tenm3 4 Dapi row 3 , S3_Tenm4 row 3 , S3_Tenm3 4 row 3
Specimen S3 row 4: embryonic day 16.5 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS24: hippocampal formation Present S3_Tenm4 row 4 , S3_Tenm3 4 row 4 , S3_Tenm3 4 Dapi row 4
Specimen S4 row 1: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S4_Tenm4 row 1 , S4_Tenm3 4 row 1 , S4_Tenm3 4 Dapi row 1
Specimen S4 row 3: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S4_Tenm4 row 3 , S4_Tenm3 4 row 3 , S4_Tenm3 4 Dapi row 3
Specimen S4 row 4: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S4_Tenm3 4 row 4 , S4_Tenm4 row 4 , S4_Tenm3 4 Dapi row 4
Specimen S5 row 1: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S5_Tenm3 4 Dapi row 1 , S5_Tenm3 4 row 1 , S5_Tenm4 row 1
Specimen S5 row 2: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S5_Tenm3 4 row 2 , S5_Tenm4 row 2 , S5_Tenm3 4 Dapi row 2
Specimen S5 row 3: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S5_Tenm3 4 row 3 , S5_Tenm4 row 3 , S5_Tenm3 4 Dapi row 3
Specimen S5 row 4: postnatal day 0 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: hippocampal formation Present S5_Tenm3 4 row 4 , S5_Tenm4 row 4 , S5_Tenm3 4 Dapi row 4
Specimen S6 row 1: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S6_Tenm4 row 1 , S6_Tenm3 4 row 1 , S6_Tenm3 4 Dapi row 1
Specimen S6 row 2: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S6_Tenm4 row 2 , S6_Tenm3 4 row 2 , S6_Tenm3 4 Dapi row 2
Specimen S6 row 4: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S6_Tenm4 row 4 , S6_Tenm3 4 row 4 , S6_Tenm3 4 Dapi row 4
Specimen S7 row 1: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S7_Tenm3 4 Dapi row 1 , S7_Tenm4 row 1 , S7_Tenm3 4 row 1
Specimen S7 row 2: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S7_Tenm4 row 2 , S7_Tenm3 4 row 2 , S7_Tenm3 4 Dapi row 2
Specimen S7 row 4: postnatal day 10 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S7_Tenm4 row 4 , S7_Tenm3 4 Dapi row 4 , S7_Tenm3 4 row 4
Specimen S8 row 2: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S8_Tenm3 4 Dapi row 2 , S8_Tenm4 row 2 , S8_Tenm3 4 row 2
Specimen S8 row 3: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S8_Tenm3 4 Dapi row 3 , S8_Tenm4 row 3 , S8_Tenm3 4 row 3
Specimen S8 row 4: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S8_Tenm3 4 row 4 , S8_Tenm3 4 Dapi row 4 , S8_Tenm4 row 4
Specimen S9 row 1: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S9_Tenm3 4 Dapi row 1 , S9_Tenm3 4 row 1 , S9_Tenm4 row 1
Specimen S9 row 2: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S9_Tenm3 4 row 2 , S9_Tenm3 4 Dapi row 2 , S9_Tenm4 row 2
Specimen S9 row 3: postnatal day 30 (more )
Note: Double labeled: magenta - Tenm4; yellow - Tenm3 (assay MGI:8259044). Sections were post-fixed in 4% paraformaldehyde.
Structure Level Pattern Image Note
TS28: hippocampal formation Present S9_Tenm3 4 Dapi row 3 , S9_Tenm4 row 3 , S9_Tenm3 4 row 3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory