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Gene Expression Data
Assay Details
Assay
Reference: J:253351 Hanley O, et al., Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8207397
Gene symbol: Hoxc9
Gene name: homeobox C9
Antibody: Anti-Hoxc9
Results
Specimen 1H Control brachial: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Absent 1H Hoxc9 Control brachial
Specimen 1H PbxMNdelta brachial: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Absent 1H Hoxc9 PbxMNdelta brachial Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen 1H Control thoracic: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Present 1H Hoxc9 Control thoracic
Specimen 1H PbxMNdelta thoracic: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Weak 1H Hoxc9 PbxMNdelta thoracic Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant. Hoxc9 levels are reduced in preganglionic motor column neurons.
Specimen S1J Control rostral: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Ambiguous Regionally restricted S1J Control rostral Hoxc9 marked the caudal region; rostral expression was not specified.
Specimen S1J PbxMNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Ambiguous Regionally restricted S1J PbxMNdelta rostral Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1J Control middle: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Ambiguous Regionally restricted S1J Control
Specimen S1J PbxMNdelta middle: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Ambiguous Regionally restricted S1J PbxMNdelta Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1J Control caudal: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Present Regionally restricted S1J Control caudal Hoxc9 marked the caudal region.
Specimen S1J PbxMNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Double labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Present Regionally restricted S1J PbxMNdelta caudal Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Specimen S1K Control left: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-. Triple labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396); blue - Isl1 (assay MGI:8206395) and Isl2 (assay MGI:8207778).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Present Regionally restricted S1K Control Hoxc6 Isl1/2 Hoxc9 Hoxc9 marked the caudal region.
Specimen S1K PbxMNdelta left: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant. Triple labeled: green - Hoxc9; red - Hoxc6 (assay MGI:8207396); blue - Isl1 (assay MGI:8206395) and Isl2 (assay MGI:8207778).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord spinal cord motor neuron Present Regionally restricted S1K PbxMNdelta Hoxc6 Isl1/2 Hoxc9 Hoxc9 rostro-caudal expression boundary is maintained in PbxMNdelta mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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