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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187721
Gene symbol: Hnf1b
Gene name: HNF1 homeobox B
Antibody: anti-HNF1B
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 1D E15.5 WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: metanephros Present 1D E15.5 WT
TS23: pancreatic duct Present 1D E15.5 WT
Specimen 1D E15.5 Sp2/+: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS23: metanephros Weak 1D E15.5 Sp2/+ Global decrease in expression.
TS23: renal tubule Present Regionally restricted 1D E15.5 Sp2/+ Expression in both non-dilated and dilated tubules.
TS23: pancreatic duct Weak 1D E15.5 Sp2/+ Decreased expression in pancreatic ducts.
Specimen 1D E17.5 WT: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: metanephros Present 1D E17.5 WT inset , 1D E17.5 WT
Specimen 1D E17.5 Sp2/+: embryonic day 17.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS25: metanephros Weak Regionally restricted 1D E17.5 Sp2/+ inset , 1D E17.5 Sp2/+ Global decrease in expression, together with decreased nuclear expression in some regions.
TS25: renal tubule Present Regionally restricted 1D E17.5 Sp2/+ inset , 1D E17.5 Sp2/+ Expression in both non-dilated and dilated tubules.
Specimen 3C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cortical early proximal tubule Present 3C
Specimen 3C': embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS23: cortical early proximal tubule Weak Regionally restricted 3C' Reduced expression compared to wild type. Proximal tubule dilatations which correlate with expression.
Specimen 4A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present 4A Co-expression with Hnf4a in proximal tubules.
Specimen 4D: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present 4D
Specimen 4G: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present 4G
Specimen 5D: embryonic day 15.5 (more )
Note: Double labeled: green - Hnf1b; red - Vil1 (assay MGI:8187726).
Structure Level Pattern Image Note
TS23: cortical early proximal tubule Present 5D
Specimen 5E/F: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: green - Hnf1b; red - Vil1 (assay MGI:8187726).
Structure Level Pattern Image Note
TS23: cortical early proximal tubule Present 5E , 5F
Specimen S3C HNF1B WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cortical early proximal tubule Present S3C HNF1B WT
Specimen S3C HNF1B Sp2/+: embryonic day 14.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS22: cortical early proximal tubule Present S3C HNF1B Sp2/+ , S3C HNF1B Sp2/+ higher mag
Specimen S8 HNF1B WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_HNF1B WT
Specimen S8 HNF1B Sp2/+: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_HNF1B Sp2/+
Specimen S8 HNF1B Hnf1a-/-: embryonic day 16.5; Hnf1atm1.1Ylee/Hnf1atm1.1Ylee (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_HNF1B Hnf1a-/- Normal expression compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory