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Gene Expression Data
Assay Details
Assay
Reference: J:181272 Le TT, et al., Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8172383
Gene symbol: Maf
Gene name: MAF bZIP transcription factor
Antibody: Anti-c-Maf
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3J: embryonic day 14.5; Rbpjtm1Hon/Rbpjtm1Hon (more )
Structure Level Pattern Image Note
TS22: lens fiber Present 3J
Specimen 3K: embryonic day 14.5; Rbpjtm1Hon/Rbpj+, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lens fiber Present 3K Similar as in the control.
Specimen 3L: embryonic day 14.5; Rbpjtm1Hon/Rbpjtm1Hon, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lens fiber Present 3L Fewer differentiated positive cells, proportional to an overall reduction in lens size.
Specimen 4A: embryonic day 11.5; Rbpjtm1Hon/Rbpjtm1Hon (more )
Note: Double labeled: red - Maf; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS19: lens vesicle Present Regionally restricted 4A Expressed in the posterior cells.
Specimen 4B: embryonic day 11.5; Rbpjtm1Hon/Rbpj+, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Maf; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS19: lens vesicle Present Regionally restricted 4B Expressed in the posterior cells, similar as in the control.
Specimen 4C: embryonic day 11.5; Rbpjtm1Hon/Rbpjtm1Hon, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Maf; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS19: lens vesicle Present Regionally restricted 4C Expressed in the posterior cells. The lens vesicle was abnormally small with a persistent connection to the surface ectoderm by means of a Cdh1+ lens stalk.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory