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Gene Expression Data
Assay Details
Assay
Reference: J:181272 Le TT, et al., Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8172381
Gene symbol: Cdkn1c
Gene name: cyclin dependent kinase inhibitor 1C
Antibody: p57Kip2 antibody
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3A: postnatal day 0; Jag1tm1Jlew/Jag1tm1Jlew (more )
Note: Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS27: lens transition zone Present 3A
Specimen 3B: postnatal day 0; Jag1tm1Jlew/Jag1+, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS27: lens transition zone Present 3B Similar as in the control.
Specimen 3C: postnatal day 0; Jag1tm1Jlew/Jag1tm1Jlew, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS27: lens transition zone Present 3C Reduced expression with a smaller lens size.
Specimen 4D: embryonic day 11.0; Jag1tm1Jlew/Jag1tm1Jlew (more )
Note: Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS18: lens vesicle Present Regionally restricted 4D Expressed in the posterior cells.
Specimen 4E: embryonic day 11.0; Jag1tm1Jlew/Jag1+, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS18: lens vesicle Present Regionally restricted 4E Expressed in the posterior cells, similar as in the control.
Specimen 4F: embryonic day 11.0; Jag1tm1Jlew/Jag1tm1Jlew, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant. Double labeled: red - Cdkn1c; green - Cdh1 (assay MGI:8172376).
Structure Level Pattern Image Note
TS18: lens vesicle Present Regionally restricted 4F Expressed in the posterior cells. The lens vesicle was abnormally small with a persistent connection to the surface ectoderm by means of a Cdh1+ lens stalk.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory