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Gene Expression Data
Assay Details
Assay
Reference: J:178173 Mastracci TL, et al., Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8161642
Gene symbol: Sst
Gene name: somatostatin
Antibody: anti-somatostatin
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 4A: postnatal day 0 (more )
Note: Double labeled: red - Sst; green - Ins1 (assay MGI:8161666) and Ins2 (assay MGI:8161916).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 4A
Specimen 4B: postnatal day 0; Arxtm1Gldn/?, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: red - Sst; green - Ins1 (assay MGI:8161666) and Ins2 (assay MGI:8161916).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 4B Increased expression compared with the wild-type (quantified in Fig 4R).
Specimen 4C: postnatal day 0; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Note: Double labeled: red - Sst; green - Ins1 (assay MGI:8161666) and Ins2 (assay MGI:8161916).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 4C Similar as in the wild-type (quantified in Fig 4R).
Specimen 4D: postnatal day 0; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: red - Sst; green - Ins1 (assay MGI:8161666) and Ins2 (assay MGI:8161916).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 4D Increased expression compared with the wild-type, similar as in the single Arx cKO (quantified in Fig 4R).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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