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Gene Expression Data
Assay Details
Assay
Reference: J:178173 Mastracci TL, et al., Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:8161244
Gene symbol: Nkx2-2
Gene name: NK2 homeobox 2
Reporter: lacZ
Antibody: anti-B-galactosidase (Abcam)
Detection system: Secondary antibody coupled to Cy2
Results
Specimen 1G: embryonic day 10.5; Nkx2-2tm3Suss/Nkx2-2+ (more )
Note: Double labeled: green - Nkx2-2 reporter; red - Arx (assay MGI:8161239).
Structure Level Pattern Image Note
TS17: pancreas primordium Present 1G Coexpression with Arx was seen.
Specimen 1I: embryonic day 10.5; Nkx2-2tm3Suss/Nkx2-2tm3Suss (more )
Note: Double labeled: green - Nkx2-2 reporter; red - Arx (assay MGI:8161239).
Structure Level Pattern Image Note
TS17: pancreas primordium Present 1I Coexpression with Arx was seen.
Specimen 1J: embryonic day 10.5; Nkx2-2tm3Suss/Nkx2-2+ (more )
Note: Double labeled: green - Nkx2-2 reporter; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS17: pancreas primordium pancreatic A cell Present 1J A subset of positive cells coexpressed with Gcg in the alpha cells.
Specimen 1L: embryonic day 10.5; Nkx2-2tm3Suss/Nkx2-2tm3Suss (more )
Note: Double labeled: green - Nkx2-2 reporter; red - Gcg (assay MGI:8161242).
Structure Cell Type Level Pattern Image Note
TS17: pancreas primordium pancreatic A cell Present 1L Expressed in the remaining Gcg-positive cells in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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