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Gene Expression Data
Assay Details
Assay
Reference: J:337458 Waldhauser V, et al., PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development. Cells. 2023 Jun 6;12(12)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7865666
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Antibody: anti-Sox10
Assay notes: Two Sox10 antibodies were described, but the one used in this assay was not detailed. Anti-Sox10 MGI:7865330 may have been used in this assay.
Results
Specimen 1A E16.5 Sox10: embryonic day 16.5 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS24: spinal cord spinal cord oligodendrocyte Present 1A E16.5 merged , 1A E16.5 Sox10 Expression in oligodendroglial cells.
Specimen 1A P0 Sox10: postnatal day 0 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS27: spinal cord spinal cord oligodendrocyte Present 1A P0 merged , 1A P0 Sox10 Expression in oligodendroglial cells.
Specimen 1A P7 Sox10: postnatal day 7 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 1A P7 merged , 1A P7 Sox10 Expression in oligodendroglial cells.
Specimen 1A P14 Sox10: postnatal day 14 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 1A P14 Sox10 , 1A P14 merged Expression in oligodendroglial cells.
Specimen 1A P21 Sox10: postnatal day 21 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 1A P21 Sox10 , 1A P21 merged Expression in oligodendroglial cells.
Specimen 2A Ctrl Sox10: postnatal day 0 (more )
Note: Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Cell Type Level Pattern Image Note
TS27: spinal cord spinal cord oligodendrocyte Present 2A Ctrl merged , 2A Ctrl Sox10 Expression in oligodendroglial cells.
Specimen 2A deltaCnp Sox10: postnatal day 0; Cnptm1(cre)Kan/Cnp+, Pbrm1tm1Zhwa/Pbrm1tm1Zhwa (more )
Note: Conditional mutant. Double labeled: green - Sox10; red - Pbrm1 (assay MGI:7865665).
Structure Level Pattern Image Note
TS27: spinal cord Present 2A deltaCnp merged , 2A deltaCnp Sox10 Total number of expressing cells comparable to control.
Specimen Ctrl P7 not shown: postnatal day 7 (more )
Note: Data shown in Figure 2D.
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present Expression in oligodendroglial cells.
Specimen deltaCnp P7 not shown: postnatal day 7; Cnptm1(cre)Kan/Cnp+, Pbrm1tm1Zhwa/Pbrm1tm1Zhwa (more )
Note: Conditional mutant. Data shown in Figure 2D.
Structure Level Pattern Image Note
TS28: spinal cord Present Total number of expressing cells comparable to control.
Specimen 4D E16.5 Ctrl: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: spinal cord spinal cord oligodendrocyte Present 4D Ctrl E16.5 Expression in oligodendroglial cells.
Specimen 4D E16.5 deltaSox10: embryonic day 16.5; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: spinal cord Present 4D deltaSox10 E16.5 Overall numbers of expressing cells comparable to wild type at E16.5,
Specimen 4D P0 Ctrl: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: spinal cord spinal cord oligodendrocyte Present 4D Ctrl P0 Expression in oligodendroglial cells.
Specimen 4D P0 deltaSox10: postnatal day 0; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: spinal cord Weak 4D deltaSox10 P0 Number of expressing cells lower than control by 23-30%..
Specimen 4D P7 Ctrl: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 4D Ctrl P7 Expression in oligodendroglial cells
Specimen 4D P7 deltaSox10: postnatal day 7; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal cord Weak 4D deltaSox10 P7 Number of expressing cells significantly lower than control.
Specimen 4D P14 Ctrl: postnatal day 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 4D Ctrl P14 Expression in oligodendroglial cells.
Specimen 4D P14 deltaSox10: postnatal day 14; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal cord Weak 4D deltaSox10 P14 Number of expressing cells significantly lower than control.
Specimen 4D P21 Ctrl: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord spinal cord oligodendrocyte Present 4D Ctrl P21 Expression in oligodendroglial cells.
Specimen 4D P21 deltaSox10: postnatal day 21; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal cord Weak 4D deltaSox10 P21 Number of expressing cells lower than control by 20-28%.
Specimen 7F P0 Ctrl: postnatal day 0 (more )
Note: Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS27: spinal cord Present 7F Ctrl P0
Specimen 7F P0 deltaSox10: postnatal day 0; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS27: spinal cord Present 7F deltaSox10 P0
Specimen 7F P7 Ctrl: postnatal day 7 (more )
Note: Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F Ctrl P7
Specimen 7F P7 deltaSox10: postnatal day 7; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F deltaSox10 P7
Specimen 7F P14 Ctrl: postnatal day 14 (more )
Note: Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F Ctrl P14
Specimen 7F P14 deltaSox10: postnatal day 14; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F deltaSox10 P14
Specimen 7F P21 Ctrl: postnatal day 21 (more )
Note: Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F Ctrl P21
Specimen 7F P21 deltaSox10: postnatal day 21; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Double labeled: green - Sox10; red - Casp3 (assay MGI:7865685).
Structure Level Pattern Image Note
TS28: spinal cord Present 7F deltaSox10 P21
Specimen P0 Ctrl not shown: postnatal day 0 (more )
Note: Data shown in Figure 8A.
Structure Cell Type Level Pattern Image Note
TS27: corpus callosum oligodendrocyte Present Expression in oligodendroglial cells.
Specimen P0 deltaSox10 not shown: postnatal day 0; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Data shown in Figure 8A.
Structure Level Pattern Image Note
TS27: corpus callosum Present
Specimen P7 Ctrl not shown: postnatal day 7 (more )
Note: Data shown in Figure 8A.
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum oligodendrocyte Present Expression in oligodendroglial cells.
Specimen P7 deltaSox10 not shown: postnatal day 7; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Data shown in Figure 8A.
Structure Level Pattern Image Note
TS28: corpus callosum Weak Significant decrease in oligodendroglial cells from P7 onwards.
Specimen P14 Ctrl not shown: postnatal day 14 (more )
Note: Data shown in Figure 8A.
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum oligodendrocyte Present Expression in oligodendroglial cells.
Specimen P14 deltaSox10 not shown: postnatal day 14; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Data shown in Figure 8A.
Structure Level Pattern Image Note
TS28: corpus callosum Weak Significant decrease in oligodendroglial cells from P7 onwards.
Specimen P21 Ctrl not shown: postnatal day 21 (more )
Note: Data shown in Figure 8A.
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum oligodendrocyte Present Expression in oligodendroglial cells.
Specimen P21 deltaSox10 not shown: postnatal day 21; Pbrm1tm1Zhwa/Pbrm1tm1Zhwa, Tg(Sox10-cre)1Wdr/0 (more )
Note: Conditional mutant. Data shown in Figure 8A.
Structure Level Pattern Image Note
TS28: corpus callosum Weak Significant decrease in oligodendroglial cells from P7 onwards.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory