Trp53 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7856702
Gene symbol:	Trp53
Gene name:	transformation related protein 53

Antibody:	anti-p53 (FL-393, sc-6243)
Detection system:	Secondary antibody
Assay notes:	Two Tpr53 antibodies were described, but the one used in this assay was not detailed. Anti-p53 MGI:7856533 may have been used in this assay.

Results

3a Control ©

Specimen 3a Control p53: embryonic day 12.5 (more

)
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt. Double labeled: red - Trp53; blue - Dcx (assay MGI:7856690).

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Ambiguous		3a Control

3a Yy1cKO ©

Specimen 3a Yy1cKO p53: embryonic day 12.5; Emx1^tm1(cre)Krj/Emx1⁺, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant. Double labeled: red - Trp53; blue - Dcx (assay MGI:7856690).

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Present		3a Yy1cKO	Authors report upregulation of expression at E12.5.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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