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Gene Expression Data
Assay Details
Assay
Reference: J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7856701
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti PAX6 (DSHB)
Detection system: Secondary antibody
Assay notes: Two Pax6 antibodies were described, but the one used in this assay was not detailed. Anti-Pax6 (PRB-278P) MGI:2157328 may have been used in this assay.
Results
Specimen S4b Control Pax6: embryonic day 12.5 (more )
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt. Double labeled: red - Pax6; green - Eomes (assay MGI:7856700).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex neuron Present Regionally restricted S4b Control Expression in apical progenitor cells. Co-expression with Tbr2 in cells transitioning from apical to basal cells.
Specimen S4b Yy1cKO Pax6: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - Eomes (assay MGI:7856700).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex neural progenitor cell Weak Regionally restricted S4b Yy1cKO Number of expressing cells decreased compared to control, but ratio of apical to basal neural progenitor cells is not affected.
Specimen S4e Control Pax6: embryonic day 15.5 (more )
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt. Double labeled: red - Pax6; green - Eomes (assay MGI:7856700).
Structure Level Pattern Image Note
TS23: cerebral cortex Present Regionally restricted S4e Control Expression in apical progenitor cells. Co-expression with Tbr2 in cells transitioning from apical to basal cells.
Specimen S4e Yy1cKO Pax6: embryonic day 15.5; Emx1tm1(cre)Krj/Emx1+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - Eomes (assay MGI:7856700).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex neural progenitor cell Weak Regionally restricted S4e Yy1cKO Number of expressing cells decreased compared to control, but ratio of apical to basal neural progenitor cells is not affected.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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