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Gene Expression Data
Assay Details
Assay
Reference: J:338696 Maynard TM, et al., Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome. Hum Mol Genet. 2020 Apr 15;29(6):1002-1017
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7713403
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Antibody: anti-betaIII tubulin
Detection system: Secondary antibody
Results
Specimen 1A: embryonic day 10.5 (more )
Structure Cell Type Level Pattern Image Note
TS17: central nervous system neuron Present 1A Expression is in differentiating neurons and axons.
TS17: cranial nerve Present 1A
TS17: trigeminal ganglion Present 1A
Specimen 1B: embryonic day 10.5; Del(16Dgcr2-Hira)1Rak/+ (more )
Structure Cell Type Level Pattern Image Note
TS17: trigeminal ganglion Present 1B In this mutant the ganglion is dysmorphic and the extension of axon fascicles is aberrant.
TS17: central nervous system neuron Present 1B Expression is in differentiating neurons and axons.
Specimen 3A WT: embryonic day 10.5 (more )
Note: Double labeled: blue - Tubb3; red - Hoxb1 (assay MGI:7713410).
Structure Level Pattern Image Note
TS17: acoustic ganglion Present 3A WT
TS17: facial ganglion Present 3A WT
TS17: hindbrain Present 3A WT
TS17: trigeminal ganglion Present 3A WT
Specimen 3A LgDel: embryonic day 10.5; Del(16Dgcr2-Hira)1Rak/+ (more )
Note: Double labeled: blue - Tubb3; red - Hoxb1 (assay MGI:7713410).
Structure Level Pattern Image Note
TS17: acoustic ganglion Present 3A LgDel
TS17: facial ganglion Present 3A LgDel
TS17: hindbrain Present 3A LgDel
TS17: trigeminal ganglion Present 3A LgDel
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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