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Gene Expression Data
Assay Details
Assay
Reference: J:211641 Bhansali P, et al., Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. Neural Dev. 2014;9:11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7645878
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: anti-Islet1/2
Results
Specimen 2A Pigmented: embryonic day 15.5; Tyrc-2J/Tyr+ (more )
Note: Double labeled: green - Isl1 and Isl2; red - Zic2 (assay MGI:7645877).
Structure Cell Type Level Pattern Image Note
TS23: retina ganglion cell layer retinal ganglion cell Present 2A Pigmented merged , 2A Pigmented Isl1/2 Expression is in postmitotic retinal ganglion cells.
Specimen 2A Albino: embryonic day 15.5; Tyrc-2J/Tyrc-2J (more )
Note: Double labeled: green - Isl1 and Isl2; red - Zic2 (assay MGI:7645877).
Structure Cell Type Level Pattern Image Note
TS23: retina ganglion cell layer retinal ganglion cell Present Regionally restricted 2A Albino Merged , 2A Albino Isl1/2 The number of positive cells in the ventrotemporal region of the mutant retina is decreased in the more central sectors (reduced by about 21%).
Specimen 2H Pigmented DT: embryonic day 15.5; Tyrc-2J/Tyr+ (more )
Structure Cell Type Level Pattern Image Note
TS23: retina ganglion cell layer retinal ganglion cell Present Regionally restricted 2H Pigmented Expression is in postmitotic retinal ganglion cells in the dorsotemporal retina.
Specimen 2H Albino DT: embryonic day 15.5; Tyrc-2J/Tyrc-2J (more )
Structure Cell Type Level Pattern Image Note
TS23: retina ganglion cell layer retinal ganglion cell Present 2H Albino Expression in this region in this mutant is the same as in controls.
Specimen 3A Pigmented: embryonic day 17.5; Tyrc-2J/Tyr+ (more )
Note: Double labeled: green - Isl1 and Isl2; red - Zic2 (assay MGI:7645877).
Structure Cell Type Level Pattern Image Note
TS25: retina ganglion cell layer retinal ganglion cell Present 3A Pigmented Expression is in postmitotic retinal ganglion cells.
Specimen 3A Albino: embryonic day 17.5; Tyrc-2J/Tyrc-2J (more )
Note: Double labeled: green - Isl1 and Isl2; red - Zic2 (assay MGI:7645877).
Structure Cell Type Level Pattern Image Note
TS25: retina ganglion cell layer retinal ganglion cell Present 3A Albino Expression in this mutant is the same as in controls.
Specimen 7A Pigmented: embryonic day 17.5; Tyrc-2J/Tyr+ (more )
Structure Cell Type Level Pattern Image Note
TS25: retina ganglion cell layer retinal ganglion cell Present 7A Pigmented merged , 7A Pigmented Isl1/2 Expression is in postmitotic retinal ganglion cells.
Specimen 7A Albino: embryonic day 17.5; Tyrc-2J/Tyrc-2J (more )
Note: Double labeled: green - Isl1 and Isl2; red - Isl2 (assay MGI:7645881).
Structure Cell Type Level Pattern Image Note
TS25: retina ganglion cell layer retinal ganglion cell Present 7A Albino Merged , 7A Albino Isl1/2 Expression in this mutant is the same as in controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory