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Gene Expression Data
Assay Details
Assay
Reference: J:338194 Sulic AM, et al., Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7574114
Gene symbol: Shh
Gene name: sonic hedgehog
Reporter: GFP
Antibody: anti-GFP
Results
Specimen 1F Shh-GFP top: embryonic day 15.5; Cyfip2tm1a(EUCOMM)Wtsi/Cyfip2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Triple labeled: green - Shh reporter; white - Cyfip2 reporter (assay MGI:7574113); magenta - Epcam (assay MGI:7574119).
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 1F Shh-GFP top , 1F merged top
Specimen 1F Shh-GFP bottom: embryonic day 15.5; Cyfip2tm1a(EUCOMM)Wtsi/Cyfip2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Triple labeled: green - Shh reporter; white - Cyfip2 reporter (assay MGI:7574113); magenta - Epcam (assay MGI:7574119).
Structure Level Pattern Image Note
TS23: hair epidermal placode Present 1F merged bottom , 1F Shh-GFP bottom
Specimen S1J Shh-GFP Control: embryonic day 15.5; Cyfip2tm1a(EUCOMM)Wtsi/Cyfip2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: green - Shh reporter; white - Epcam (assay MGI:7574119).
Structure Level Pattern Image Note
TS23: hair epidermal placode Present Regionally restricted S1J EpCAM Shh-GFP Control Localization of expression at tip of invading hair germ.
Specimen S1J Shh-GFP LacZ/LacZ: embryonic day 15.5; Cyfip2tm1a(EUCOMM)Wtsi/Cyfip2tm1a(EUCOMM)Wtsi, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: green - Shh reporter; white - Epcam (assay MGI:7574119).
Structure Level Pattern Image Note
TS23: hair epidermal placode Present Regionally restricted S1J EpCAM Shh-GFP LacZ/LacZ Localization of expression unaffected at E15.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory