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Gene Expression Data
Assay Details
Assay
Reference: J:338243 Christova T, et al., LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity. EMBO Rep. 2023 Jul 5;24(7):e56937
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7544890
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6 (#PRB-278P; #30130, #901301)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A WT Sox2/Pax6: embryonic day 15.5 (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:7544888).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex ventricular layer forebrain radial glial cell Present Regionally restricted 1A WT Sox2/Pax6 , 1A WT Pax6 Expression was detected in the apical radial glial progenitor cells.
Specimen 1A DKO Sox2/Pax6: embryonic day 15.5; Alktm1Swm/Alktm1Swm, Ltktm1Rabr/Ltktm1Rabr (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:7544888).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex ventricular layer forebrain radial glial cell Present Regionally restricted 1A DKO Sox2/Pax6 , 1A DKO Pax6 Expression was detected in the apical radial glial progenitor cells, similar to wild type.
Specimen EV2A WT Sox2/Pax6: embryonic day 15.5 (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:7544888).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex ventricular layer forebrain radial glial cell Present Regionally restricted EV2A WT Pax6 , EV2A WT Sox2/Pax6 Expression was detected in the apical radial glial progenitor cells.
Specimen EV2A Alk-/- Sox2/Pax6: embryonic day 15.5; Alktm1Swm/Alktm1Swm (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:7544888).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex ventricular layer forebrain radial glial cell Present Regionally restricted EV2A Alk-/- Sox2/Pax6 , EV2A Alk-/- Pax6 Expression was detected in the apical radial glial progenitor cells, similar to wild type.
Specimen EV2A Ltk-/- Sox2/Pax6: embryonic day 15.5; Ltktm1Rabr/Ltktm1Rabr (more )
Note: Double labeled: red - Pax6; green - Sox2 (assay MGI:7544888).
Structure Cell Type Level Pattern Image Note
TS23: cerebral cortex ventricular layer forebrain radial glial cell Present Regionally restricted EV2A Ltk-/- Sox2/Pax6 , EV2A Ltk-/- Pax6 Expression was detected in the apical radial glial progenitor cells, similar to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory