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Gene Expression Data
Assay Details
Assay
Reference: J:293794 Durbin MD, et al., SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7531404
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody
Results
Specimen S2D: embryonic day 14.5 (more )
Note: Double labeled: red - Casp3; green - Tnnt2 (assay MGI:7531370).
Structure Cell Type Level Pattern Image Note
TS22: left ventricle cardiac muscle cardiac muscle cell Present Single cells S2F , S2D
Specimen S2E: embryonic day 14.5; Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor (more )
Note: Double labeled: red - Casp3; green - Tnnt2 (assay MGI:7531370).
Structure Cell Type Level Pattern Image Note
TS22: left ventricle cardiac muscle cardiac muscle cell Present Single cells S2E , S2G There is trend, though not statistically significant, towards decreased apoptosis in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory