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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7511558
Gene symbol: Prkca
Gene name: protein kinase C, alpha
Antibody: anti-PKCalpha (610107)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen S6G: postnatal month 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Prkca; red - Mpp4 (assay MGI:7511559).
Structure Cell Type Level Pattern Image Note
TS28: retina retinal bipolar neuron Present S6G
Specimen S6H: postnatal month 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Prkca; red - Mpp4 (assay MGI:7511559).
Structure Cell Type Level Pattern Image Note
TS28: retina outer plexiform layer retinal bipolar neuron Present S6H The mutant immunopositive bipolar cells showed loss of the dendritic tree.
TS28: retina outer nuclear layer retinal bipolar neuron Present S6H Misplaced bipolar cell nuclei were noted in the outer nuclear layer.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory