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Gene Expression Data
Assay Details
Assay
Reference: J:321845 Bernhardt N, et al., Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. eNeuro. 2022 Mar-Apr;9(2):ENEURO.0518-21.2022
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7509781
Gene symbol: Rbfox3
Gene name: RNA binding protein, fox-1 homolog (C. elegans) 3
Antibody: anti-NeuN
Assay notes: Two Rbfox3 antibodies were described, but the one used in this assay was not detailed. Anti-NeuN MGI:7509750 may have been used in this assay.
Results
Specimen 2C control: postnatal (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord neuron Present 2C control
Specimen 2C hop: postnatal; Ift56hop/Ift56hop (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord neuron Present Regionally restricted 2C hop Morphology of lumbar part severely affected. More rostral and caudal parts were unaffected.
Specimen 2C' control: postnatal (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord lumbar region neuron Present 2C' control
Specimen 2C' hop: postnatal; Ift56hop/Ift56hop (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord lumbar region neuron Present Regionally restricted 2C' hop Diffuse border between neurons and ventral area.
Specimen 2E NeuN: postnatal day 5 (more )
Note: Double labeled: red - Rbfox3; green - Mbp (assay MGI:7509782).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord gray matter neuron Present 2E inset , 2E
Specimen 2F NeuN: postnatal day 5; Ift56hop/Ift56hop (more )
Note: Double labeled: red - Rbfox3; green - Mbp (assay MGI:7509782).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord neuron Present Regionally restricted 2F , 2F inset Authors report misplaced neurons.
Specimen 2M NeuN: postnatal adult (more )
Note: Double labeled: red - Rbfox3; green - Mbp (assay MGI:7509782).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord gray matter neuron Present 2M inset , 2M
Specimen 2N NeuN: postnatal adult; Ift56hop/Ift56hop (more )
Note: Double labeled: red - Rbfox3; green - Mbp (assay MGI:7509782).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord neuron Present Regionally restricted 2N inset , 2N Authors report misplaced neurons.
Specimen 5A: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: spinal cord neuron Present 5A
Specimen 5B: embryonic day 15.5; Ift56hop/Ift56hop (more )
Structure Cell Type Level Pattern Image Note
TS23: spinal cord neuron Present Regionally restricted 5B Authors report fused spinal cord.
Specimen 7G: embryonic day 16.5; Ift56em1Kldr/Ift56em1Kldr (more )
Structure Cell Type Level Pattern Image Note
TS24: spinal cord neuron Present Regionally restricted 7G , 7G inset Border between white and gray matter was poorly defined.
Specimen 7H: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: spinal cord neuron Present 7H inset , 7H
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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