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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7506992
Gene symbol: Opn1mw
Gene name: opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
Antibody: anti-red/green Opsin (#AB5405)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 7G: postnatal day 10; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: red - Opn1mw; green - Rho (assay MGI:7506988).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal cone cell Present 7G
Specimen 7H: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: red - Opn1mw; green - Rho (assay MGI:7506988).
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space retinal cone cell Present Regionally restricted 7H Some misplaced nuclei in the subretinal space were M-opsin-positive.
Specimen S5A: postnatal day 10; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal cone cell Present S5A
Specimen S5B: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space retinal cone cell Present Regionally restricted S5B Some immunopositive cone photoreceptors were misplaced in the subretinal space of the cKO.
Specimen S5C: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space retinal cone cell Present Regionally restricted S5C Some immunopositive cone photoreceptors were misplaced in the subretinal space of the cKO.
Specimen S5D: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space retinal cone cell Present Regionally restricted S5D Some immunopositive cone photoreceptors were misplaced in the subretinal space of the cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory