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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7506988
Gene symbol: Rho
Gene name: rhodopsin
Antibody: Anti-Rhodopsin (1D4; AB5356)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 7C: postnatal day 6; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Rho; red - Rcvrn (assay MGI:7506986).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal rod cell Present 7C Rhodopsin is a marker for mature rod photoreceptors.
Specimen 7D: postnatal day 6; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Rho; red - Rcvrn (assay MGI:7506986).
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space retinal rod cell Present Regionally restricted 7D Some ectopic nuclei were detected in the subretinal space throughout the retina. Some were positive for both Rhodopsin and Recoverin.
Specimen 7G: postnatal day 10; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Rho; red - Opn1mw (assay MGI:7506992).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal rod cell Present 7G
Specimen 7H: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Rho; red - Opn1mw (assay MGI:7506992).
Structure Cell Type Level Pattern Image Note
TS28: intraretinal space photoreceptor cell Present Regionally restricted 7H Most of the ectopic nuclei were detected in the subretinal space throughout the retina.
Specimen 7I: postnatal month 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Rho; red - Rcvrn (assay MGI:7506986).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal rod cell Present Regionally restricted 7I Expression was localized in the outer segments of the photoreceptors.
Specimen 7J: postnatal month 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Rho; red - Rcvrn (assay MGI:7506986).
Structure Cell Type Level Pattern Image Note
TS28: retina retinal rod cell Present Regionally restricted 7J In the knockout retina there was a reduced length of the segments, and some ectopic cytoplasmic localization of staining was noted.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory