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Gene Expression Data
Assay Details
Assay
Reference: J:126484 Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
Assay type: RNA in situ
MGI Accession ID: MGI:7481266
Gene symbol: Ret
Gene name: ret proto-oncogene
Probe: Ret probe
Probe preparation: labelled with fluorescein RNA
Results
Specimen 1A E12: embryonic day 12.0 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS20: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 1A E12 Expression in only a few neurons. Many have large-diameter soma and do not coexpress TrkA.
Specimen 1A E16: embryonic day 16.0 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS24: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 1A E16 Coexpression with TrkA in many neurons.
Specimen 1A P0: postnatal day 0 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 1A P0 Coexpression with TrkA in many neurons.
Specimen 1A P5: postnatal day 5 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 1A P5
Specimen 1A P10: postnatal day 10 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 1A P10
Specimen 1A P14: postnatal day 14 (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 1A P14 Segregation of neurons expressing TrkA from those expressing Ret nearly complete.
Specimen 1B: postnatal day 14 (more )
Note: Double labeled: green - Ret; red - Gfra1 (assay MGI:7481268).
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 1B Ret , 1B Overlay Overlap with Gfra1 expression in 18.2% of neurons.complete.
Specimen 1C: postnatal day 14 (more )
Note: Double labeled: green - Ret; red - Gfra2 (assay MGI:7481271).
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Weak Regionally restricted 1C Ret , 1C Overlay Overlap with Gfra2 expression in 61.4% of cells.
Specimen 1D: postnatal day 14 (more )
Note: Double labeled: green - Ret; red - Gfra3 (assay MGI:7481274).
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Weak Regionally restricted 1D Overlay , 1D Ret Overlap with Gfra3 expression in 13.9% of neurons.
Specimen 1E: postnatal day 14 (more )
Note: Double labeled: green - Ret; red - all GFRs.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted 1E Overlay , 1E Ret Coexpression with at least one of GFRs in 99% of neurons.
Specimen S2B: postnatal day 0; Baxtm1Sjk/Baxtm1Sjk, Ngftm1Gne/Ngf+ (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Strong Regionally restricted S2B Overlay , S2B Ret Strongly Ret-expressing neurons are early expressing populations that do not coexpress TrkA.
Specimen S2C: postnatal day 0; Baxtm1Sjk/Baxtm1Sjk, Ngftm1Gne/Ngftm1Gne (more )
Note: Double labeled: green - Ret; red - TrkA (Ntrk1 assay MGI:7481265).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Weak Single cells S2C Ret , S2C Overlay Remaining Ret-expressing neurons do not express TrkA.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory