Myo7a Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:299026 Kannan-Sundhari A, et al., Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7470859
Gene symbol:	Myo7a
Gene name:	myosin VIIA

Antibody:

anti-Myo7a (MYO7A 138-1)

Results

1B Merge ©

1B MYOD7A ©

Specimen 1B: postnatal day 0 (more

)
Note: Double labeled: red - Myo7a; green - Brd4 (assay MGI:7470855).

Structure	Cell Type	Level	Pattern	Image	Note
TS27: organ of Corti	cochlea auditory hair cell	Present	Regionally restricted	1B Merge , 1B MYOD7A	Expression is in hair cells.

1E +/+ Merge ©

1E +/+ MYOD7A ©

Specimen 1E control: postnatal day 8 (more

)
Note: Double labeled: red - Myo7a; green - Brd4 (assay MGI:7470855).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlea auditory hair cell	Present	Regionally restricted	1E +/+ Merge , 1E +/+ MYOD7A	Expression is in hair cells.

1E -/- Merge ©

1E -/- MYOD7A ©

Specimen 1E: postnatal day 8; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant. Double labeled: red - Myo7a; green - Brd4 (assay MGI:7470855).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlea auditory hair cell	Present	Regionally restricted	1E -/- MYOD7A , 1E -/- Merge

4A +/+ P8 ©

Specimen 4A Brd4^+/+ P8: postnatal day 8 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	4A +/+ P8	Expression is in hair cells.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	4A +/+ P8	Expression is in hair cells.

4A Atoh1-Brd4^-/- P8 ©

Specimen 4A Atoh1-Brd4^-/- P8: postnatal day 8; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	4A Atoh1-Brd4^-/- P8	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	4A Atoh1-Brd4^-/- P8	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.

4A +/+ P21 ©

Specimen 4A Brd4^+/+ P21: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	4A +/+ P21	Expression is in hair cells.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	4A +/+ P21	Expression is in hair cells.

4A Atoh1-Brd4^-/- P21 ©

Specimen 4A Atoh1-Brd4^-/- P21: postnatal day 21; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	4A Atoh1-Brd4^-/- P21	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	4A Atoh1-Brd4^-/- P21	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.

S3A +/+ Base ©

Specimen S3A Brd4^+/+ Base: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A +/+ Base	Expression is in hair cells.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A +/+ Base	Expression is in hair cells.

S3A +/+ Middle ©

Specimen S3A Brd4^+/+ Middle: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A +/+ Middle	Expression is in hair cells.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A +/+ Middle	Expression is in hair cells.

S3A +/+ Apex ©

Specimen S3A Brd4^+/+ Apex: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A +/+ Apex	Expression is in hair cells.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A +/+ Apex	Expression is in hair cells.

Specimen S3A Atoh1-Brd4^-/- Base: postnatal day 21; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Base	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Base	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.

Specimen S3A Atoh1-Brd4^-/- Middle: postnatal day 21; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Middle	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Middle	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.

Specimen S3A Atoh1-Brd4^-/- Apex: postnatal day 21; Brd4^{tm1c(EUCOMM)Wtsi}/Brd4^{tm1c(EUCOMM)Wtsi}, Tg(Atoh1-cre)1Bfri/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: organ of Corti	cochlear inner hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Apex	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.
TS28: organ of Corti	cochlear outer hair cell	Present	Regionally restricted	S3A Atoh1-Brd4^-/- Apex	Staining in this mutant illustrated severe hair cell loss compared to controls with more outer hair cell death.

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