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Gene Expression Data
Assay Details
Assay
Reference: J:253585 Siletti K, et al., Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11170-E11179
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7427539
Gene symbol: Dvl2
Gene name: dishevelled segment polarity protein 2
Antibody: Dvl2 antibody
Detection system: Secondary antibody
Assay notes: Fixation was with TCA.
Results
Specimen 6A: postnatal day 0 (more )
Note: Double labeled: magenta - Dvl2; green - Daple (Ccdc88c assay MGI:7427531).
Structure Cell Type Level Pattern Image Note
TS27: cochlea cochlea auditory hair cell Present 6A Dishevelled-2 , 6A Merged
Specimen 7B Daple+/-: postnatal day 0; Ccdc88ctm1(KOMP)Mbp/Ccdc88c+ (more )
Note: Double labeled: magenta - Dvl2; green - ZO-1 (Tjp1 assay MGI:7427542).
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 7B Dishevelled-2 Daple+/- , 7B Merged Daple+/- Expression at tight junctions near apex of cochlea.
Specimen 7B Daple-/-: postnatal day 0; Ccdc88ctm1(KOMP)Mbp/Ccdc88ctm1(KOMP)Mbp (more )
Note: Double labeled: magenta - Dvl2; green - ZO-1 (Tjp1 assay MGI:7427542).
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 7B Dishevelled-2 Daple-/- , 7B Merged Daple-/- Expression at abneural edges near apex of cochlea.
Specimen 7C Daple+/-: postnatal day 0; Ccdc88ctm1(KOMP)Mbp/Ccdc88c+ (more )
Note: Double labeled: magenta - Dvl2; green - ZO-1 (Tjp1 assay MGI:7427542).
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 7C Merged Daple+/- , 7C Dishevelled-2 Daple+/- Expression localized asymmetrically near base of cochlea.
Specimen 7D Daple-/-: postnatal day 0; Ccdc88ctm1(KOMP)Mbp/Ccdc88ctm1(KOMP)Mbp (more )
Note: Double labeled: magenta - Dvl2; green - ZO-1 (Tjp1 assay MGI:7427542).
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 7C Dishevelled-2 Daple-/- , 7C Merged Daple-/- Expression absent from abneural edges near base of cochlea.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory