About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:239360 Zhang Y, et al., Dynamic expression of Lgr6 in the developing and mature mouse cochlea. Front Cell Neurosci. 2015;9:165
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7335247
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Cy5
Results
Specimen 1A: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present Regionally restricted 1A Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 1B E15.5 Apical: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 1B-1-2 , 1B-1-4 , 1B-1-5 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 1B E15.5 Middle: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 1B-2-2 , 1B-2-4 , 1B-2-5 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 1B E15.5 Basal: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 1B-3-4 , 1B-3-5 , 1B-3-2 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 1B E18.5 Apical: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlear inner hair cell Present 1B-4-4 , 1B-4-5 , 1B-4-2
TS26: organ of Corti cochlear outer hair cell Present 1B-4-4 , 1B-4-5 , 1B-4-2
TS26: organ of Corti organ of Corti supporting cell Present 1B-4-4 , 1B-4-5 , 1B-4-2
TS26: cochlear duct epithelium Present Regionally restricted 1B-4-5 , 1B-4-4 , 1B-4-2 Expressed in the greater epithelium region.
Specimen 1B E18.5 Middle: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlear inner hair cell Present 1B-5-5 , 1B-5-2 , 1B-5-4
TS26: organ of Corti cochlear outer hair cell Present 1B-5-5 , 1B-5-2 , 1B-5-4
TS26: organ of Corti organ of Corti supporting cell Present 1B-5-5 , 1B-5-2 , 1B-5-4
TS26: cochlear duct epithelium Present Regionally restricted 1B-5-2 , 1B-5-4 , 1B-5-5 Expressed in the greater epithelium region.
Specimen 1B E18.5 Basal: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlear inner hair cell Ambiguous 1B-6-4 , 1B-6-5 , 1B-6-2 Expression was down-regulated in more differentiated hair cells in the basal region.
TS26: organ of Corti cochlear outer hair cell Ambiguous 1B-6-4 , 1B-6-5 , 1B-6-2 Expression was down-regulated in more differentiated hair cells in the basal region.
TS26: organ of Corti organ of Corti supporting cell Present 1B-6-5 , 1B-6-2 , 1B-6-4
TS26: cochlear duct epithelium Present Regionally restricted 1B-6-5 , 1B-6-4 , 1B-6-2 Expressed in the greater epithelium region.
Specimen 2A E15.5 Apical: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A-1-4 , 2A-1-5 , 2A-1-3 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 2A E15.5 Middle: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A-2-3 , 2A-2-5 , 2A-2-4 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 2A E15.5 Basal: embryonic day 15.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2A-3-4 , 2A-3-5 , 2A-3-3 Expressed in the prosensory region that gives rise to the organ of Corti.
Specimen 2A E18.5 Apical: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct epithelium Present Regionally restricted 2A-4-5 , 2A-4-3 , 2A-4-4 Expressed in the greater epithelium region.
TS26: organ of Corti cochlear inner hair cell Present 2A-4-3 , 2A-4-4 , 2A-4-5
TS26: organ of Corti cochlear outer hair cell Present 2A-4-3 , 2A-4-4 , 2A-4-5
TS26: organ of Corti organ of Corti supporting cell Present 2A-4-3 , 2A-4-4 , 2A-4-5
Specimen 2A E18.5 Middle: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlear inner hair cell Present 2A-5-5 , 2A-5-3 , 2A-5-4
TS26: organ of Corti cochlear outer hair cell Present 2A-5-5 , 2A-5-3 , 2A-5-4
TS26: organ of Corti organ of Corti supporting cell Present 2A-5-5 , 2A-5-3 , 2A-5-4
TS26: cochlear duct epithelium Present Regionally restricted 2A-5-3 , 2A-5-4 , 2A-5-5 Expressed in the greater epithelium region.
Specimen 2A E18.5 Basal: embryonic day 18.5; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti cochlear inner hair cell Ambiguous 2A-6-4 , 2A-6-3 , 2A-6-5 Expression was down-regulated in more differentiated hair cells in the basal region.
TS26: organ of Corti cochlear outer hair cell Ambiguous 2A-6-4 , 2A-6-3 , 2A-6-5 Expression was down-regulated in more differentiated hair cells in the basal region.
TS26: cochlear duct epithelium Present Regionally restricted 2A-6-5 , 2A-6-4 , 2A-6-3 Expressed in the greater epithelium region.
TS26: organ of Corti organ of Corti supporting cell Present 2A-6-5 , 2A-6-3 , 2A-6-4
Specimen 3D section Apical: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-1-4 , 3D-1-5 , 3D-1-2
Specimen 3D section Middle: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-2-5 , 3D-2-2 , 3D-2-4
Specimen 3D section Basal: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-3-4 , 3D-3-2 , 3D-3-5
Specimen 3D wholemount Apical: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-4-2 , 3D-4-5 , 3D-4-4
Specimen 3D wholemount Middle: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-5-5 , 3D-5-2 , 3D-5-4
Specimen 3D wholemount Basal: postnatal day 1; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present 3D-6-2 , 3D-6-5 , 3D-6-4
Specimen 4 Apical P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Apical-3 , 4_Apical-2 , 4_Apical-4
TS28: organ of Corti organ of Corti supporting cell Present 4_Apical-3 , 4_Apical-2 , 4_Apical-4
Specimen 4 Apical P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present 4_Apical-6
Specimen 4 Apical P15: postnatal day 15; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Apical-8
TS28: organ of Corti organ of Corti supporting cell Present 4_Apical-8
Specimen 4 Middle P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Middle-4 , 4_Middle-2 , 4_Middle-3
TS28: organ of Corti internal pillar cell of cochlea Present 4_Middle-4 , 4_Middle-2 , 4_Middle-3
TS28: organ of Corti organ of Corti supporting cell Present 4_Middle-4 , 4_Middle-2 , 4_Middle-3
Specimen 4 Middle P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Middle-6
TS28: organ of Corti internal pillar cell of cochlea Present 4_Middle-6
TS28: organ of Corti organ of Corti supporting cell Present 4_Middle-6
Specimen 4 Middle P15: postnatal day 15; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Middle-8
TS28: organ of Corti internal pillar cell of cochlea Present 4_Middle-8
TS28: organ of Corti organ of Corti supporting cell Present 4_Middle-8
Specimen 4 Basal P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Basal-2 , 4_Basal-3 , 4_Basal-4
TS28: organ of Corti internal pillar cell of cochlea Present 4_Basal-2 , 4_Basal-3 , 4_Basal-4
TS28: organ of Corti organ of Corti supporting cell Present 4_Basal-2 , 4_Basal-3 , 4_Basal-4
Specimen 4 Basal P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Basal-6
TS28: organ of Corti internal pillar cell of cochlea Present 4_Basal-6
TS28: organ of Corti organ of Corti supporting cell Present 4_Basal-6
Specimen 4 Basal P15: postnatal day 15; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti border cell of cochlea Present 4_Basal-8
TS28: organ of Corti internal pillar cell of cochlea Present 4_Basal-8
TS28: organ of Corti organ of Corti supporting cell Present 4_Basal-8
Specimen 5A Apical P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-1-2
Specimen 5A Apical P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-1-4
Specimen 5A Apical P15: postnatal day 15; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-1-6
Specimen 5A Middle P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-2-2
Specimen 5A Middle P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-2-4
Specimen 5A Middle P15: postnatal day 15; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-2-6
Specimen 5A Basal P7: postnatal day 7; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-3-2
Specimen 5A Basal P10: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-3-4
Specimen 5A Basal P15: postnatal day 10; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Double labeled: red - Sox2; green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 5A-3-6
Specimen 6A P20 upper: postnatal day 20; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 6A-1-2 , 6A-1-5 , 6A-1-4
Specimen 6A P20 lower: postnatal day 20; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 6A-2-5 , 6A-2-4 , 6A-2-2
Specimen 6A P30: postnatal day 30; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct epithelium organ of Corti supporting cell Present 6A-3-2 , 6A-3-4 , 6A-3-5
Specimen S1 Apical: postnatal day 3; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present S1_Apical-5 , S1_Apical-4 , S1_Apical-2
Specimen S1 Middle: postnatal day 3; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present S1_Middle-2 , S1_Middle-4 , S1_Middle-5
Specimen S1 Basal: postnatal day 3; Lgr6tm2.1(cre/ERT2)Cle/Lgr6+ (more )
Note: Triple labeled: red - Sox2; white - Myo7a (assay MGI:7335961); green - Lgr6 (assay MGI:7335244).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium organ of Corti supporting cell Present S1_Basal-5 , S1_Basal-4 , S1_Basal-2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory