Lgr6^{tm2.1(cre/ERT2)Cle}
Targeted Allele Detail

Summary

• Symbol: Lgr6^{tm2.1(cre/ERT2)Cle}
• Name: leucine-rich repeat-containing G protein-coupled receptor 6; targeted mutation 2.1, Hans Clevers
• MGI ID: MGI:4438349
• Synonyms: Lgr6-EGFP, Lgr6-EGFP-Ires-CreERT2
• Gene: Lgr6 Location: Chr1:134911039-135033014 bp, - strand Genetic Position: Chr1, 58.24 cM
• Alliance: Lgr6^{tm2.1(cre/ERT2)Cle} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157895
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Lgr6^{tm2.1(cre/ERT2)Cle} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lgr6 (MGI:2441805)

• Mutation details: An EGFP-IRES-CreERT2 cassette was inserted at the transcriptional start site along with a loxP-flanked neomycin cassette by homologous recombination. The neomycin gene was then removed by cre mediated recombination. EGFP expression is driven by the endogenous promoter. Cre expression is induced by tamoxifen treatment. (J:157895)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lgr6 (mouse) Summary of all recombinase alleles driven by Lgr6. Comparative matrix view of recombinase activities Alliance mouse Lgr6 gene page

Expression

In Mice Carrying this Mutation:

276 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lgr6 Mutation: 84 strains or lines available

References

• Original: J:157895 Snippert HJ, et al., Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
• All: 32 reference(s)