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Gene Expression Data
Assay Details
Assay
Reference: J:326361 Li S, et al., Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh1(3*HA-P2A-Cre) knockin mouse strain. Dev Dyn. 2022 Jul;251(7):1156-1174
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7327508
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Y-17; sc-17320)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2D': postnatal day 1; Atoh1em1(cre)Zyliu/Atoh1+ (more )
Note: Triple labeled: red - Sox2; gray - Atoh1 reporter (assay MGI:7327506); green - Myo6 (assay MGI:7327507).
Structure Cell Type Level Pattern Image Note
TS27: cochlea supporting cell of cochlea Present 2D'
Specimen 2H': postnatal day 5; Atoh1em1(cre)Zyliu/Atoh1+ (more )
Note: Triple labeled: red - Sox2; gray - Atoh1 reporter (assay MGI:7327506); green - Myo6 (assay MGI:7327507).
Structure Cell Type Level Pattern Image Note
TS28: cochlea supporting cell of cochlea Present 2H'
Specimen 4C: embryonic day 11.5; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Insm1 (assay MGI:7327511); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS19: hindbrain neural progenitor cell Present 4C
TS19: otocyst epithelium Present 4C
TS19: acoustic ganglion neural progenitor cell Present 4C
Specimen 4D'',D''': embryonic day 11.5; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Insm1 (assay MGI:7327511); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS19: hindbrain neural progenitor cell Present 4D'' , 4D'''
Specimen 4E'',E''': embryonic day 11.5; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Insm1 (assay MGI:7327511); red - Cre reporter.
Structure Level Pattern Image Note
TS19: otocyst epithelium Present 4E'' , 4E'''
Specimen 4F'',F''': embryonic day 11.5; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Insm1 (assay MGI:7327511); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS19: acoustic ganglion neural progenitor cell Present 4F'' , 4F'''
Specimen 8A': postnatal day 1; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo7a (assay MGI:7327512); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: cochlea Hensen cell Present 8A'
TS27: cochlea cochlear inner hair cell Absent 8A'
TS27: cochlea cochlear outer hair cell Absent 8A'
Specimen 8B': postnatal day 1; Atoh1tm1(cre)Gan/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo7a (assay MGI:7327512); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: cochlea Hensen cell Present
TS27: cochlea cochlear inner hair cell Absent
TS27: cochlea cochlear outer hair cell Absent
Specimen 8D': postnatal day 1; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo7a (assay MGI:7327512); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Deiter's cell Present 8D'
TS27: organ of Corti pillar cell Present 8D'
Specimen 8E': postnatal day 1; Atoh1tm1(cre)Gan/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo7a (assay MGI:7327512); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Deiter's cell Present 8E'
TS27: organ of Corti Hensen cell Present 8E'
TS27: organ of Corti pillar cell Present 8E'
Specimen 8G': postnatal day 1; Atoh1em1(cre)Zyliu/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo6 (assay MGI:7327507); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Hensen cell Present 8G'
TS27: organ of Corti cochlear inner hair cell Absent 8G'
TS27: organ of Corti cochlear outer hair cell Absent 8G'
Specimen 8H': postnatal day 1; Atoh1tm1(cre)Gan/Atoh1+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: gray - Sox2; green - Myo6 (assay MGI:7327507); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Hensen cell Present 8H'
TS27: organ of Corti cochlear inner hair cell Absent 8H'
TS27: organ of Corti cochlear outer hair cell Absent 8H'
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory