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Gene Expression Data
Assay Details
Assay
Reference: J:132315 Lynn FC, et al., MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007 Dec;56(12):2938-45
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7266727
Gene symbol: Ins1
Gene name: insulin I
Antibody: anti-insulin
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 3C: embryonic day 18.5; Dicer1tm1Bdh/Dicer1+, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: green - Ins1 and Ins2; red - Gcg (assay MGI:7266729).
Structure Cell Type Level Pattern Image Note
TS26: endocrine pancreas type B pancreatic cell Present 3C
Specimen 3D: embryonic day 18.5; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: green - Ins1 and Ins2; red - Gcg (assay MGI:7266729).
Structure Cell Type Level Pattern Image Note
TS26: endocrine pancreas type B pancreatic cell Trace 3D Near-complete (94%) loss of beta cells compared with comtrol.
Specimen 4A: postnatal month 8 (more )
Note: Double labeled: green - Ins1 and Ins2; red - Gcg (assay MGI:7266729).
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas type B pancreatic cell Present 4A
Specimen 4B: postnatal month 8; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Ins2-cre)25Mgn/0 (more )
Note: Conditional mutant. Double labeled: green - Ins1 and Ins2; red - Gcg (assay MGI:7266729).
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas type B pancreatic cell Present 4B Expression in beta cells normal compared with control.
Specimen not shown: embryonic day 18.5; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Neurog3-cre/Esr1*)1Dam/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: endocrine pancreas Present Authors report normal islet cell expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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