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Gene Expression Data
Assay Details
Assay
Reference: J:271138 Coulter ME, et al., The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 Jul 24;24(4):973-986.e8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6726349
Gene symbol: Chmp1a
Gene name: charged multivesicular body protein 1A
Antibody: Chmp1a antibody (15761-1-AP)
Detection system: Alexa Fluor
Results
Specimen 2B Chmp1a: postnatal day 0 (more )
Note: Double labeled: red - Chmp1a; green - Calbindin (Calb1 assay MGI:6726348).
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present Regionally restricted 2B Chmp1a , 2B Merge Expression in Purkinje cell cytoplasm and dendrites; expression absent from nucleus.
TS27: cerebellum external granule cell layer Absent 2B Merge , 2B Chmp1a
Specimen 2E Chmp1a: embryonic day 14.5 (more )
Note: Triple labeled: red - Chmp1a; green - Ctip2 (Bcl11b assay MGI:6726345); pink - Sox2 (assay MGI:6726350).
Structure Level Pattern Image Note
TS22: cortical plate Present 2E Chmp1a , 2E Merge Expression in postmitotic neurons in cerebral cortex.
TS22: cerebral cortex subventricular zone Absent 2E Chmp1a , 2E Merge No expression in progenitors.
TS22: cerebral cortex ventricular layer Absent 2E Chmp1a , 2E Merge No expression in progenitors.
Specimen S3A Chmp1a: postnatal day 0 (more )
Note: Triple labeled: red - Chmp1a; green - Aqp1 (assay MGI:6726354); blue - Hoechst.
Structure Level Pattern Image Note
TS27: 4th ventricle choroid plexus epithelium Present Punctate S3A Punctate expression in epithelial cells of hindbrain choroid plexus.
Specimen S3D Control: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebellum Present S3D CHMP1A WT
Specimen S3D Chmp1a null: postnatal day 0; Chmp1aGt(XC472)Byg/Chmp1aGt(XC472)Byg (more )
Structure Level Pattern Image Note
TS27: cerebellum Absent S3D CHMP1A Chmp1a null
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory