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Gene Expression Data
Assay Details
Assay
Reference: J:297161 Javali A, et al., Modulation of beta-catenin levels regulates cranial neural crest patterning and dispersal into first pharyngeal arch. Dev Dyn. 2020 May 19;
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6505463
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Results
Specimen 3He: embryonic day 9.5; E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: trigeminal preganglion Strong 3He High levels of expression in proximal region (trigeminal ganglion anlage).
Specimen 3Hf: embryonic day 9.5; E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: 1st branchial arch mesenchyme derived from neural crest Weak Regionally restricted 3Hf Reduced expression in distal region (skeletogenic cells) in first pharyngeal arch.
Specimen 4A 4SS: embryonic day 8.0 (more )
Note: 4 somites. Double labeled: red - Ctnnb1; white - Tfap2a (assay MGI:6505461).
Structure Level Pattern Image Note
TS12: migrating neural crest Present Uniform 4A 4SS Uniform levels of membrane expression in entire pool of delaminated cranial neural crest cells (CNCC).
Specimen 4Aa: embryonic day 8.0 (more )
Note: 4 somites. Double labeled: red - Ctnnb1; white - Tfap2a (assay MGI:6505461).
Structure Level Pattern Image Note
TS12: migrating neural crest Present Uniform 4Aa (right) , 4Aa (center) Uniform levels of membrane expression in entire pool of delaminated cranial neural crest cells (CNCC).
Specimen 4A 8SS: embryonic day 8.5 (more )
Note: 8 somites. Double labeled: red - Ctnnb1; white - Tfap2a (assay MGI:6505461).
Structure Level Pattern Image Note
TS13: migrating neural crest Weak Regionally restricted 4A 8SS Decreased levels of expression in distally migrated cranial neural crest cells (CNCC).
Specimen 4Ab: embryonic day 8.5 (more )
Note: 8 somites. Double labeled: red - Ctnnb1; white - Tfap2a (assay MGI:6505461).
Structure Level Pattern Image Note
TS13: migrating neural crest Weak Regionally restricted 4Ab (center) , 4Ab (right) Decreased levels of expression in distally migrated cranial neural crest cells (CNCC).
Specimen 4Ac: embryonic day 8.5 (more )
Note: 8 somites. Double labeled: red - Ctnnb1; white - Tfap2a (assay MGI:6505461).
Structure Level Pattern Image Note
TS13: migrating neural crest Weak Regionally restricted 4Ac (right) , 4Ac (center) Decreased levels of expression in distally migrated cranial neural crest cells (CNCC).
Specimen 7B beta-catenin: embryonic day 9.5; Ctnnb1tm1Mmt/Ctnnb1+, E2f1Tg(Wnt1-cre)2Sor/0 (more )
Note: Conditional mutant. Double labeled: red - Ctnnb1; green - Twist1 (assay MGI:6505464).
Structure Level Pattern Image Note
TS15: 1st branchial arch mesenchyme derived from neural crest Strong 7B (left) High levels of expression in hypoplastic pharyngeal arch.
Specimen 7B beta-catenin inset: embryonic day 9.5; Ctnnb1tm1Mmt/Ctnnb1+, E2f1Tg(Wnt1-cre)2Sor/0 (more )
Note: Conditional mutant. Double labeled: red - Ctnnb1; green - Twist1 (assay MGI:6505464).
Structure Level Pattern Image Note
TS15: 1st branchial arch mesenchyme derived from neural crest Strong Regionally restricted 7B (center right) , 7B (right) High levels of expression in Twist1-expressing cells in hypoplastic pharyngeal arch.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory