Rho Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:293626 Allon G, et al., PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation. Hum Mol Genet. 2019 Dec 15;28(24):4078-4088
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6469335
Gene symbol:	Rho
Gene name:	rhodopsin

Antibody:	anti-rhodopsin
Detection system:	Secondary antibody coupled to Cy3

Results

Specimen 1B: postnatal adult (more

)
Note: Double labeled: green - Rho; red - Prcd (assay MGI:6469334)

Structure	Level	Pattern	Image	Note
TS28: photoreceptor layer	Present	Regionally restricted	1D , 1C	Expression is seen in rod photoreceptors.

Specimen 8A WT 9 am: postnatal week 5 (more

)

Structure	Level	Pattern	Image	Note
TS28: photoreceptor layer outer segment	Present		8A 9 am WT
TS28: pigmented retinal epithelium	Strong	Punctate	8A 9 am WT	Round spheres (marking phagocytosed outer segment discs) are observed within the RPE.

Specimen 8A -/- 9 am: postnatal week 5; Prcd^{tm1.1(KOMP)Mbp}/Prcd^{tm1.1(KOMP)Mbp} (more

)

Structure	Level	Pattern	Image	Note
TS28: photoreceptor layer outer segment	Present		8A 9 am Prcd-/-
TS28: pigmented retinal epithelium	Trace	Punctate	8A 9 am Prcd-/-	Minimal numbers of round spheres (marking phagocytosed outer segment discs) are observed within the RPE; the numbers in the mutant are markedly reduced from those seen in wild type.

Specimen 8A WT 1 pm: postnatal week 5 (more

)

Structure	Level	Pattern	Image	Note
TS28: photoreceptor layer outer segment	Present		8A 1 pm WT
TS28: pigmented retinal epithelium	Weak	Punctate	8A 1 pm WT	Round spheres (marking phagocytosed outer segment discs) are observed within the RPE; their numbers are markedly reduced from earlier in the day.

Specimen 8A -/- 1 pm: postnatal week 5; Prcd^{tm1.1(KOMP)Mbp}/Prcd^{tm1.1(KOMP)Mbp} (more

)

Structure	Level	Pattern	Image	Note
TS28: photoreceptor layer outer segment	Present		8A 1 pm Prcd-/-
TS28: pigmented retinal epithelium	Ambiguous		8A 1 pm Prcd-/-	Minimal numbers of round spheres (marking phagocytosed outer segment discs) are observed within the RPE; the numbers in the mutant are markedly reduced from those seen in wild type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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