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Gene Expression Data
Assay Details
Assay
Reference: J:294838 Li X, et al., Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors. Cereb Cortex. 2020 Jun 1;30(7):3960-3976
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6459951
Gene symbol: Xpo1
Gene name: exportin 1
Results
Specimen 1a E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 1a E11.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
Specimen 1a E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebral cortex intermediate zone Present 1a E13.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS21: cerebral cortex subventricular zone Present 1a E13.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS21: cerebral cortex ventricular layer Present 1a E13.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS21: cortical plate Present 1a E13.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
Specimen 1a E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present 1a E15.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS23: cerebral cortex subventricular zone Present 1a E15.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS23: cerebral cortex ventricular layer Present 1a E15.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
TS23: cortical plate Present 1a E15.5 Expression in ventricular zone, subventricular zone, intermediate zone and cortical plate from E11.5 to E15.
Specimen 1a E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Present Regionally restricted 1a E16.5 By E16.5, expression waned in germinal zone.
TS24: cortical plate Present 1a E16.5 Expression remained strong in cortical plate.
Specimen 1a Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer V Present 1a Adult Expression only in layer V or cortex.
Specimen 1b E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1b E13.5
TS21: cerebral cortex ventricular layer Present 1b E13.5
TS21: cortical plate Present 1b E13.5
Specimen 1b CP: embryonic day 13.5 (more )
Note: Double labeled: red - Crm1 (Xpo1); green - Tbr1 (assay MGI:6459952).
Structure Level Pattern Image Note
TS21: cortical plate Present Regionally restricted 1b CP Merge , 1b CP Crm1 Expression localized in early postmitotic neurons.
Specimen 1b SVZ/VZ: embryonic day 13.5 (more )
Note: Double labeled: red - Crm1 (Xpo1); green - Tbr2 (Eomes assay MGI:6459953).
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present Regionally restricted 1b SVZ/VZ Crm1 , 1b SVZ/VZ Merge Expression in intermediate progenitors.
TS21: cerebral cortex ventricular layer Present Regionally restricted 1b SVZ/VZ Crm1 , 1b SVZ/VZ Merge Expression in intermediate progenitors.
Specimen 1b VZ: embryonic day 13.5 (more )
Note: Double labeled: red - Crm1 (Xpo1); green - Nestin (Nes assay MGI:6459954).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 1b VZ Merge , 1b VZ Crm1 Expression in neural progenitors.
Specimen 1c Metaphase: embryonic day 13.5 (more )
Note: Double labeled: red - Crm1 (Xpo1); green - alpha-tubulin.
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 1c Metaphase Crm1 , 1c Metaphase alpha-Tubulin/Crm1 Expression in mitotic cell located in ventricular zone. Punctate expression detected in and near spindle microtubules.
Specimen 1c Magnified: embryonic day 13.5 (more )
Note: Double labeled: red - Crm1 (Xpo1); green - alpha-tubulin.
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 1c Magnified , 1c Magnified (inset) alpha-Tubulin/Crm1 , 1c Magnified (inset) Crm1 Expression at tip of mitoric spindles close to condensed chromatin in metaphase cells.
Specimen 3a E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3a E14.5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory