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Gene Expression Data
Assay Details
Assay
Reference: J:206541 Engelhard C, et al., MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013;2:e01160
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6451176
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Reporter: lacZ
Direct Detection
Results
Specimen 5A left: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS17: eye Strong 5A E10.5
TS17: head Strong Regionally restricted 5A E10.5 There is strong expression in the dorsal portion of the face above the eye.
Specimen 5A right: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: head Present 5A E11.5
Specimen 5B +/+: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: head Present 5B bottom row - left , 5B top row - left
Specimen 5B -/-: embryonic day 11.5; Bmp4tm2Blh/Bmp4+, Megf8tm1.1Ddg/Megf8tm1.1Ddg (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: head Present Regionally restricted 5B top row - center , 5B bottom row - center In the mutant expression is disrupted in the area around the opthalmic branch of the trigeminal nerve but is intact throughout the rest of the embryo.
Specimen 5B flox/flox; cre: embryonic day 11.5; Bmp4tm2Blh/Bmp4+, Megf8tm1.2Ddg/Megf8tm1.2Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: head Present Regionally restricted 5B top row - right , 5B bottom row - right In the mutant expression is disrupted in the area around the opthalmic branch of the trigeminal nerve.
Specimen 5 S1A left: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: embryo Present Widespread 5 S1A left
Specimen 5 S1A right: embryonic day 11.5; Bmp4tm2Blh/Bmp4+, Megf8tm1.1Ddg/Megf8tm1.1Ddg (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: embryo Present Widespread 5 S1A right Expression is disrupted in the area around the ophthalmic branch of the trigeminal nerve but is intact throughout the rest of the embryo.
Specimen 5 S1B left: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: embryo Present Widespread 5 S1B left
Specimen 5 S1B right: embryonic day 11.5; Bmp4tm2Blh/Bmp4+, Megf8tm1.1Ddg/Megf8tm1.1Ddg (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: embryo Present Widespread 5 S1B right
Specimen 5 S1C left: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: forelimb bud Present 5 S1C left
TS19: hindlimb bud Present 5 S1C left
Specimen 5 S1C right: embryonic day 11.5; Bmp4tm2Blh/Bmp4+, Megf8tm1.1Ddg/Megf8tm1.1Ddg (more )
Note: Double labeled: blue - Bmp4; brown - Nefm (assay MGI:6451144)
Structure Level Pattern Image Note
TS19: forelimb bud Present 5 S1C right
TS19: hindlimb bud Present 5 S1C right
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory