About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400918
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 4G mut: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - Trp53 (assay MGI:6400915).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 4G The vast majority of Trp53-upregulating cells in the mutant pallium were Pax6-immunopositive radial glial cells, a significant enrichment compared with the percentage of Pax6-immunopositive radial glial cells in the mutant pallium (93.6%).
Specimen S2B: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - Casp3 (assay MGI:6400589).
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted S2B , S2B'' , S2B' The widespread cytoplasmic staining in Pax6+ radial glial cells was co-localized with cleaved-Casp3 staining.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory