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Gene Expression Data
Assay Details
Assay
Reference: J:166528 Zacharias AL, et al., Canonical Wnt/beta-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn. 2010 Dec;239(12):3215-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388680
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Antibody: anti-beta-catenin
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 1A: embryonic day 10.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+.
Structure Level Pattern Image Note
TS17: eye Present Widespread 1A Expression throughout tissues of the developing eye.
TS17: head blood vessel Present Regionally restricted 1A Expression in mesoderm-derived endothelium of blood vessels.
TS17: head mesenchyme derived from neural crest Present Regionally restricted 1A Expression in neural crest surrounding the eye.

Specimen 1E: embryonic day 10.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: eye Present Widespread 1E Expression throughout tissues of the developing eye.
TS17: head blood vessel Present Regionally restricted 1E Expression in mesoderm-derived endothelium of blood vessels.
TS17: head mesenchyme derived from neural crest Absent 1E Expression undetectable in neural crest surrounding the eye.

Specimen 2A/C: embryonic day 10.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS17: eye Present Widespread 2A , 2C
TS17: head mesenchyme derived from neural crest Absent 2C , 2A Expression undetectable in neural crest surrounding the eye.

Specimen 2D: embryonic day 10.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS17: eye Present Widespread 2D
TS17: head mesenchyme derived from neural crest Present Regionally restricted 2D

Specimen 2E/G: embryonic day 11.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS19: eye Present Widespread 2E , 2G
TS19: head mesenchyme derived from neural crest Absent 2G , 2E Expression undetectable in neural crest surrounding the eye.

Specimen 2H: embryonic day 11.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS19: eye Present Widespread 2H
TS19: head mesenchyme derived from neural crest Present Regionally restricted 2H Expression in neural crest surrounding the eye.

Specimen 2I/K: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS20: eye Present Widespread 2I , 2K
TS20: head mesenchyme derived from neural crest Absent 2K , 2I Expression undetectable in neural crest surrounding the eye.

Specimen 2L: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+. Double labeled: green - Ctnnb1; red - Pitx2 (assay MGI:6388681).
Structure Level Pattern Image Note
TS20: eye Present Widespread 2L
TS20: head mesenchyme derived from neural crest Present Regionally restricted 2L Expression in neural crest surrounding the eye.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory