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Gene Expression Data
Assay Details
Assay
Reference: J:281434 Sato Y, et al., Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain. Gene Expr Patterns. 2019 Sep 12;34:119070
Assay type: RNA in situ
MGI Accession ID: MGI:6384838
Gene symbol: Elmo2
Gene name: engulfment and cell motility 2
Probe: Elmo2 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2A Elmo2 B6: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: inferior colliculus Strong 2A Elmo2 B6
TS25: cerebral cortex Strong Regionally restricted 2A Elmo2 B6 Expression in superficial part of cerebral cortex high compared to that of Elmo1 and Elmo3.
TS25: dentate gyrus Present Regionally restricted 2A Elmo2 B6 Expression in dentate gyrus granule cells higher than that of Elmo1 and Elmo3.
TS25: telencephalon ventricular layer Present 2A Elmo2 B6 Expression in ventricular zone surrounding lateral ventricles.
TS25: thalamus Weak 2A Elmo2 B6
Specimen 2A Elmo2 rl: embryonic day 17.0; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS25: brain Present Regionally restricted 2A Elmo2 rl Authors report overall expression not severely affect by the mutation.
TS25: cerebral cortex Present Regionally restricted 2A Elmo2 rl Authors report layer-dependent expression seemed affected at E17.
Specimen 3A Elmo2: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Strong 3A Elmo2
TS28: hippocampus Strong 3A Elmo2
TS28: inferior colliculus Strong 3A Elmo2
TS28: lateral dorsal thalamic nucleus Strong 3A Elmo2
TS28: main olfactory bulb Strong 3A Elmo2
Specimen 3B Elmo2 (upper): postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: lateral ventricle ependyma Present 3B Elmo2 (upper) Expression in ventricular zone or surrounding lateral ventricles.
Specimen 3B Elmo2 (middle): postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Strong 3B Elmo2 (middle)
TS28: inferior colliculus Strong 3B Elmo2 (middle)
TS28: piriform cortex Strong 3B Elmo2 (middle)
Specimen 3B Elmo2 (lower): postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 3B Elmo2 (lower)
TS28: paraflocculus Present 3B Elmo2 (lower)
Specimen 3C Elmo2 (center): postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: lateral dorsal thalamic nucleus Strong Regionally restricted 3C Elmo2 (center)
Specimen 3C Elmo2 (right): postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 3C Elmo2 (right)
Specimen 4A Elmo2 WT: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: inferior colliculus Strong 4A Elmo2 WT
Specimen 4A Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted 4A Elmo2 rl Authors report regional expression patterns roughly similar to thos in B6 mouse brains.
Specimen 4C Elmo1 + Elmo2 WT: postnatal day 21 (more )
Note: Double labeled: green - Elmo2; magenta - Elmo1 (assay MGI:6384837).
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted 4C WT
Specimen 4C Elmo1 + Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Note: Double labeled: green - Elmo2; magenta - Elmo1 (assay MGI:6384837).
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted 4C rl Authors report different cellular expression patterns compared with that of B6 brains.
Specimen 5A Elmo2 (1st row): postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: taenia tecta Present Regionally restricted 5A Elmo2 (1st row) Notatable expression in dorsal tenia tecta.
Specimen 5A Elmo2 (2nd row): postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: indusium griseum Present 5A Elmo2 (2nd row)
Specimen 5A Elmo2 (3rd row): postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: hippocampus Strong Regionally restricted 5A Elmo2 (3rd row) High expression in hippocampus. Higher expression in cells around layer II/III.
TS28: amygdala Present 5A Elmo2 (3rd row)
Specimen 5A Elmo2 (4th row): postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: dorsomedial hypothalamic nucleus Present 5A Elmo2 (4th row)
TS28: medial habenular nucleus Strong 5A Elmo2 (4th row)
TS28: piriform cortex Strong Regionally restricted 5A Elmo2 (4th row) High expression in piriform cortex in vicinity of intermediate-high expression in cells of lateral olfactory tract and olfactory tubercle.
Specimen 5B Elmo2: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: amygdala Present 5B Elmo2 In amygdala, espression of Elmo2 more affected than that of Elmo1 and Elmo3.
Specimen 5D Elmo2 B6: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: amygdala Present 5D B6
Specimen 5D Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: amygdala Present 5D rl In amygdala, espression of Elmo2 more affected than that of Elmo1 and Elmo3.
Specimen 6A Elmo1 + Elmo2: embryonic day 17.0 (more )
Note: Double labeled: green - Elmo2; magenta - Elmo1 (assay MGI:6384837).
Structure Level Pattern Image Note
TS25: cerebral cortex Strong Regionally restricted 6A Elmo1 Elmo2 Expression in superficial part of cerebral cortex high compared to that of Elmo1 and Elmo3.
Specimen 6B Elmo2 (left): postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: neocortex layer Strong Regionally restricted 6B Elmo2 Higher expression in cells around layer II/III.
Specimen 6B Elmo2 + Calbindin: postnatal day 21 (more )
Note: Double labeled: blue - Elmo2; brown - Calb1 (assay MGI:6384842).
Structure Level Pattern Image Note
TS28: frontal cortex Present Regionally restricted 6B Elmo2 Calbindin Majority of expression cells in upper layer of frontal cortex were Calb1-expressing cells of layer II/III.
Specimen 6C Elmo2 B6: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: parietal cortex Present Regionally restricted 6C B6
Specimen 6C Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: parietal cortex Present Regionally restricted 6C rl Layer-specific expression in parietal cortex seems disturbed in reeler mutant.
Specimen 7A Elmo2: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: hippocampus Strong 7A Elmo2
TS28: dentate gyrus Present 7A Elmo2 Characteristic pattern of expression in dentate gyrus.
Specimen 7B Elmo2 B6: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present 7B Elmo2 B6
TS28: hippocampus CA3 Present 7B Elmo2 B6
TS28: dentate gyrus granule cell layer Strong 7B Elmo2 B6
Specimen 7B Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 7B Elmo2 rl
TS28: hippocampus Present 7B Elmo2 rl
Specimen 7C Elmo2 B6: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present 7C Elmo2 B6
TS28: hippocampus CA3 Present 7C Elmo2 B6
TS28: subiculum Present 7C Elmo2 B6
Specimen 7C Elmo2 rl: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 7C Elmo2 rl
TS28: hippocampus Present 7C Elmo2 rl
Specimen 8B Elmo2: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present 8B Elmo2
Specimen 8B Elmo2 inset: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Regionally restricted 8B Elmo2 inset Higher expression distributed unevenly in superficial area of granule cell layer (side of marginal zone between granule cell layer and molecular layer) than in cells in deeper layer (near subgranular zone).
Specimen 8C Elmo2 sagittal: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present 8C sagittal
Specimen 8C Elmo2 coronal: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 8C coronal
TS28: hippocampus Present 8C coronal
Specimen 9A Elmo2 P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 9A Elmo2 P7
Specimen 9A Elmo2 P21: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 9A Elmo2 P21
Specimen 9B Elmo2: postnatal day 21; Relnrl/Relnrl (more )
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 9B Elmo2 Expressing cells localized around outer rim area of cerebellum.
Specimen 10A Elmo2 P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 10A Elmo2 P7
TS28: cerebellum internal granule cell layer Present 10A Elmo2 P7
Specimen 10A Elmo2 P21: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 10A Elmo2 P21
TS28: cerebellum molecular layer Present Regionally restricted 10A Elmo2 P21 Expression in basket cells of molecular layer.
Specimen 10B Elmo2 + GFAP: postnatal day 21 (more )
Note: Double labeled: blue - Elmo2; brown - Gfap (assay MGI:6384845).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Regionally restricted 10B Elmo2 GFAP Exprssion in Gfap-expressing Bergmann glial cells with cell bodies in the Purkinje cell layer.
Specimen 10B Elmo2 + Calbindin: postnatal day 21 (more )
Note: Double labeled: blue - Elmo2; brown - Calb1 (assay MGI:6384842).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Regionally restricted 10B Elmo2 Calbindin Exprssion in Calb1-negative Bergmann glial cells with cell bodies in the Purkinje cell layer.
Specimen Elmo2 E17 not shown: embryonic day 17.0 (more )
Note: Data presented in Table 1.
Structure Level Pattern Image Note
TS25: neocortex Strong
TS25: inferior colliculus Present
TS25: main olfactory bulb Present
TS25: medulla oblongata Present
TS25: telencephalon ventricular layer Present
TS25: corpus striatum Weak
TS25: hippocampus marginal layer Weak
TS25: pons Weak
TS25: rhombic lip Weak
TS25: superior colliculus Weak
TS25: thalamus Weak
Specimen Elmo2 P21 not shown: postnatal day 21 (more )
Note: Data presented in Table 1.
Structure Level Pattern Image Note
TS28: anterior olfactory nucleus Strong
TS28: cerebellum Purkinje cell layer Strong
TS28: dentate gyrus Strong
TS28: dentate gyrus granule cell layer Strong
TS28: hippocampus Strong
TS28: main olfactory bulb Strong
TS28: piriform cortex Strong
TS28: olfactory tract Strong Regionally restricted Expression in lateral olfactory tract.
TS28: cerebellum granule cell layer Present
TS28: cerebellum internal granule cell layer Present
TS28: cortical layer II Present
TS28: cortical layer III Present
TS28: frontal cortex Present
TS28: hippocampus CA1 Present
TS28: hippocampus CA3 Present
TS28: hippocampus pyramidal cell layer Present
TS28: indusium griseum Present
TS28: inferior colliculus Present
TS28: lateral dorsal thalamic nucleus Present
TS28: lateral septal nucleus Present
TS28: medial habenular nucleus Present
TS28: neocortex Present
TS28: olfactory tubercle Present
TS28: paraflocculus Present
TS28: primary motor cortex Present
TS28: primary somatosensory cortex Present
TS28: taenia tecta Present
TS28: accumbens nucleus Weak
TS28: anterior medial cortex Weak
TS28: auditory cortex Weak
TS28: basolateral amygdaloid nucleus Weak
TS28: brain ventricle Weak
TS28: caudate-putamen Weak
TS28: central amygdaloid nucleus Weak
TS28: central lateral thalamic nucleus Weak
TS28: cingulate cortex Weak
TS28: corpus striatum Weak
TS28: cortical amygdaloid nucleus Weak
TS28: cortical layer IV Weak
TS28: cortical layer V Weak
TS28: cortical layer VI Weak
TS28: cuneate nucleus Weak
TS28: dentate gyrus molecular layer Weak
TS28: dorsomedial hypothalamic nucleus Weak
TS28: ectorhinal area Weak
TS28: endopiriform nucleus Weak
TS28: entorhinal cortex Weak
TS28: globus pallidus Weak
TS28: hippocampus stratum lacunosum Weak
TS28: hippocampus stratum oriens Weak
TS28: hippocampus stratum radiatum Weak
TS28: inferior olivary nucleus Weak
TS28: infralimbic area Weak
TS28: lateral amygdaloid nucleus Weak
TS28: lateral geniculate nucleus Weak
TS28: lateral habenular nucleus Weak
TS28: lateral posterior thalamic nucleus Weak
TS28: lateral ventricle Weak
TS28: lateral ventricle ependyma Weak
TS28: mammillary body Weak
TS28: medial amygdaloid nucleus Weak
TS28: medial dorsal thalamic nucleus Weak
TS28: medulla oblongata Weak
TS28: midbrain Weak
TS28: orbital area Weak
TS28: parafascicular nucleus Weak
TS28: perirhinal cortex Weak
TS28: pons Weak
TS28: primary visual cortex Weak
TS28: red nucleus Weak
TS28: secondary motor cortex Weak
TS28: solitary tract nucleus Weak
TS28: somatic motor system Weak
TS28: subiculum Weak
TS28: substantia nigra Weak
TS28: superior colliculus Weak
TS28: superior olivary nucleus Weak
TS28: temporal cortex association area Weak
TS28: ventral medial thalamic nucleus Weak
TS28: ventral tegmental area Weak
TS28: vestibular nucleus Weak
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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