About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:136720 Friedrichs M, et al., Lamination of the cerebral cortex is disturbed in Gli3 mutant mice. Dev Biol. 2008 Jun 1;318(1):203-14
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6383071
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-Tbr1
Results
Specimen 3A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cortical plate Strong 3A
TS20: cortical preplate Strong 3A
Specimen 3F: embryonic day 12.5; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS20: cortical plate Strong Regionally restricted 3F The dorsomedial expression domain in this mutant is thinner compared to wild-type.
TS20: cortical preplate Strong Regionally restricted 3F The dorsomedial expression domain in this mutant is thinner compared to wild-type.
Specimen 3K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cortical plate Present 3K
Specimen 3P: embryonic day 14.5; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS22: cortical plate Present Regionally restricted 3P The dorsomedial expression domain is absent in this mutant.
Specimen 5G: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cortical layer VI Strong 5G , 5G'
TS27: cortical subplate Strong 5G , 5G'
TS27: cerebral cortex marginal zone Strong Regionally restricted 5G' , 5G Expression is in Cajal Retzius neurons.
TS27: cortical layer II Weak 5G' , 5G
TS27: cortical layer III Weak 5G' , 5G
Specimen 5H: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present Regionally restricted 5H , 5H' In this mutant expresssing cells are positioned close to the ventricular surface.
TS27: cerebral cortex marginal zone Present 5H' , 5H Expression in this mutant did not resemble Cajal Retzius expression.
Specimen 8B: postnatal day 0 (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8C , 8B
Specimen 8E: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8E , 8F The laminar organization is disrupted in this mutant.
Specimen 8H: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8H , 8I The laminar organization is disrupted in this mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory