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Gene Expression Data
Assay Details
Assay
Reference: J:136720 Friedrichs M, et al., Lamination of the cerebral cortex is disturbed in Gli3 mutant mice. Dev Biol. 2008 Jun 1;318(1):203-14
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6383071
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-Tbr1
Results
Specimen 3A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cortical plate Strong 3A
TS20: cortical preplate Strong 3A
Specimen 3F: embryonic day 12.5; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS20: cortical plate Strong Regionally restricted 3F The dorsomedial expression domain in this mutant is thinner compared to wild-type.
TS20: cortical preplate Strong Regionally restricted 3F The dorsomedial expression domain in this mutant is thinner compared to wild-type.
Specimen 3K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cortical plate Present 3K
Specimen 3P: embryonic day 14.5; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS22: cortical plate Present Regionally restricted 3P The dorsomedial expression domain is absent in this mutant.
Specimen 5G: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cortical layer VI Strong 5G , 5G'
TS27: cortical subplate Strong 5G , 5G'
TS27: cerebral cortex marginal zone Strong Regionally restricted 5G' , 5G Expression is in Cajal Retzius neurons.
TS27: cortical layer II Weak 5G' , 5G
TS27: cortical layer III Weak 5G' , 5G
Specimen 5H: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present Regionally restricted 5H , 5H' In this mutant expresssing cells are positioned close to the ventricular surface.
TS27: cerebral cortex marginal zone Present 5H' , 5H Expression in this mutant did not resemble Cajal Retzius expression.
Specimen 8B: postnatal day 0 (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8C , 8B
Specimen 8E: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8E , 8F The laminar organization is disrupted in this mutant.
Specimen 8H: postnatal day 0; Gli3Pdn/Gli3Xt-J (more )
Note: Double labeled: green - Tbr1; red - Nes (assay MGI:6383090).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 8H , 8I The laminar organization is disrupted in this mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory