About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:256989 King R, et al., Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genet. 2018 Jan;14(1):e1007145
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6187963
Gene symbol: Pou6f2
Gene name: POU domain, class 6, transcription factor 2
Antibody: anti-POU6F2
Detection system: Alexa Fluor 488
Results
Specimen 6A: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: neural retina Strong Regionally restricted 6A Prominent expression in neuroblasts destined to become retinal ganglion cells.
TS24: cornea epithelium Present Regionally restricted 6A Expression in corneal epithelium and corneal stem cells.
Specimen ganglion cell layer: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present Expression in many cells in ganglion cell layer.
Specimen 7A/D: postnatal adult (more )
Note: Flat mount. Triple labeled: green - Pou6f2; red - Rbpms (assay MGI:6187964); blue - TOPRO-3.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 7D , 7A Authors report expression in only a small percentage of total number of cells in ganglion cell layer.
Specimen Young D2: postnatal month 2 (more )
Note: Data shown in Figure 8.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present
Specimen Aged D2: postnatal month 8 (more )
Note: Data shown in Figure 8.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Weak Authors report a 73% loss of expressing retinal ganglion cells (RGCs) in aged DBA/2J mice compared to young DBA/2J mice.
Specimen cornea and sclera: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cornea Absent
TS28: sclera Absent
Specimen 9A: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: corneo-scleral junction Present 9A Expression in line of cells at junction of cornea and sclera.
Specimen 9D/F: postnatal adult (more )
Note: Flat mount. Triple labeled: green - Pou6f2; red - Abcb5 (assay MGI:6187965); blue - TOPRO-3.
Structure Level Pattern Image Note
TS28: corneo-scleral junction Present 9D , 9F Expression in many cells in the limbus.
Specimen S4A: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present S4A
Specimen S4B: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted S4B Expression in amacrine cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory