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Gene Expression Data
Assay Details
Assay
Reference: J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5697549
Gene symbol: Krt8
Gene name: keratin 8
Antibody: TROMA 1
Detection system: Secondary antibody
Results
Specimen Ext. 2A: postnatal (more )
Note: Whisker pad. Double labeled: red - Krt8; blue - Nefh (assay MGI:5697548).
Structure Level Pattern Image Note
TS28: face skin Present Single cells Extended Data 2A Krt8 , Extended Data 2A Merge Expression is present in Merkel cells in whisker pads.
Specimen Ext. 2B: postnatal (more )
Note: dorsal skin
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 2B Merge , Extended Data 2B Krt8 Expression is present in Merkel cells in touch domes in hairy skin.
Specimen Ext. 2C: postnatal (more )
Note: foot pad
Structure Level Pattern Image Note
TS28: autopod skin Present Single cells Extended Data 2C Merge , Extended Data 2C Krt8 Expression is present in Merkel cells in glabrous (nonhairy) skin.
Specimen 1B: postnatal; Piezo2tm1.1(cre)Apat/Piezo2tm1.1(cre)Apat (more )
Note: Whisker pad. Double labeled: red - Krt8; green - Piezo2 reporter (assay MGI:5697408).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 1B Krt8 , 1B GFP/Krt8 Expression is present in Merkel cells in whisker pads.
Specimen 1C: postnatal; Piezo2tm1.1(cre)Apat/Piezo2tm1.1(cre)Apat (more )
Note: Whisker pad. Triple labeled: red - Krt8; blue - Nefh (assay MGI:5697548); green - Piezo2 reporter (assay MGI:5697408).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 1C Krt8 , 1D GFP/Krt8/Nefh , 1C GFP/Krt8/Nefh Expression is present in Merkel cells in whisker pads.
Specimen 1E: postnatal; Piezo2tm1.1(cre)Apat/Piezo2tm1.1(cre)Apat (more )
Note: Dorsal skin. Double labeled: red - Krt8; green - Piezo2 reporter (assay MGI:5697408).
Structure Level Pattern Image Note
TS28: back skin Present Single cells 1E GFP/Krt8 , 1E Krt8 Expression is present in Merkel cells in touch domes in hairy skin.
Specimen 1F: postnatal; Piezo2tm1.1(cre)Apat/Piezo2tm1.1(cre)Apat (more )
Note: Foot pad. Double labeled: red - Krt8; green - Piezo2 reporter (assay MGI:5697408).
Structure Level Pattern Image Note
TS28: autopod skin Present Single cells 1F GFP/Krt8 , 1F Krt8 Expression is present in Merkel cells in glabrous (nonhairy) skin.
Specimen 2D: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat (more )
Note: Whisker pad. Double labeled: red - Krt8; green - Piezo2 (assay MGI:5697547).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 2D Krt8 , 2D Krt8/Piezo2 Expression is present in Merkel cells in whisker pads.
Specimen 2E: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Whisker pad. Double labeled: red - Krt8; green - Piezo2 (assay MGI:5697547).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 2E Krt8 , 2E Krt8/Piezo2 As in wild type, epression is present in Merkel cells in whisker pads.
Specimen 2F: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Whisker pad. Triple labeled: red - Krt8; blue - Nefh (assay MGI:5697548); green - Piezo2 (assay MGI:5697547).
Structure Level Pattern Image Note
TS28: face skin Present Single cells 2F Krt8/Piezo2/Nefh , 2F Krt8 As in wild type, expression is present in Merkel cells in whisker pads.
Specimen Ext. 4E: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat (more )
Note: Dorsal skin. Double labeled: red - Krt8; green - Nefh (assay MGI:5697548).
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 4E Merge , Extended Data 4E Krt8 Expression is present in Merkel cells in touch domes in hairy skin.
Specimen Ext. 4F/G: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat (more )
Note: Dorsal skin. Triple labeled: red - Krt8; green - Nefh (assay MGI:5697548); blue - Slc17a6 (assay MGI:5697836).
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 4G Merge , Extended Data 4G Krt8/Nefh , Extended Data 4G Krt8/VGLUT2 , Extended Data 4F Krt8 Expression is present in Merkel cells in touch domes in hairy skin.
Specimen Ext. 4J: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Dorsal skin. Double labeled: red - Krt8; green - Nefh (assay MGI:5697548).
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 4J Krt8 , Extended Data 4J Merge As in wild type, expression is present in Merkel cells in touch domes in hairy skin.
Specimen Ext. 4K: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Dorsal skin. Double labeled: red - Krt8; green - Slc17a6 (assay MGI:5697836).
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 4K Krt8 , Extended Data 4K Merge As in wild type, expression is present in Merkel cells in touch domes in hairy skin.
Specimen Ext. 4L: postnatal; Piezo2tm2.2Apat/Piezo2tm2.2Apat, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Dorsal skin. Triple labeled: red - Krt8; green - Nefh (assay MGI:5697548); blue - Slc17a6 (assay MGI:5697836).
Structure Level Pattern Image Note
TS28: back skin Present Single cells Extended Data 4L Krt8/Nefh , Extended Data 4L Merge As in wild type, expression is present in Merkel cells in touch domes in hairy skin.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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