About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:150757 Mak AC, et al., Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development. Gene Expr Patterns. 2009 Sep;9(6):444-53
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5439828
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-SOX2 (GT15098)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A,C: embryonic day 9.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS15: otocyst Strong Regionally restricted 1C , 1A Expression in the proneural region, stronger on the ventral side of the otic vesicle.
TS15: future hindbrain Present Regionally restricted 1C , 1A Expression in the hindbrain adjacent to the otocyst.
Specimen 2A,A": embryonic day 10.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 2A" , 2A In anterior sections, expression on the ventro-lateral side of the otocyst.
Specimen 2B,B": embryonic day 10.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 2B" , 2B Two domains of expression, one on the lateral side and one on the ventral side of the otocyst.
TS17: acoustic ganglion Present Regionally restricted 2B" , 2B Expression in delaminating neuroblasts on the boundary of the vestibular ganglion.
Specimen 2C,C": embryonic day 10.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 2C" , 2C In more posterior sections, expression in two domains on the medial side of the otocyst.
Specimen 3A,A": embryonic day 12.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS20: semicircular canal Present Regionally restricted 3A , 3A" Expression in prosensory domain of lateral crista.
Specimen 3B,B": embryonic day 12.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS20: semicircular canal Present Regionally restricted 3B , 3B" Expression in prosensory domain of anterior crista.
Specimen 3C,C": embryonic day 12.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS20: cochlear duct Present Regionally restricted 3C , 3C" Expression in prosensory domain of cochlear duct/organ of Corti.
Specimen 3D: embryonic day 12.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS20: utricle Present Regionally restricted 3D Expression in prosensory domain of utricular macula. Expression in both hair and suppporting cells.
Specimen 3E: embryonic day 12.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS20: semicircular canal Present Regionally restricted 3E Expression in prosensory domain of posterior crista.
Specimen 4A,A": embryonic day 14.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: semicircular canal Present Regionally restricted 4A , 4A" Expression in both hair and supporting cells of the anterior and lateral crista.
Specimen 4B,B": embryonic day 14.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: semicircular canal Present Regionally restricted 4B" , 4B Expression in both hair and supporting cells of the posterior crista.
Specimen 4C: embryonic day 14.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: utricle Present Regionally restricted 4C Expression in both hair and supporting cells of the utricular macula.
Specimen 4D: embryonic day 14.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: saccule Present Regionally restricted 4D Expression in both hair and supporting cells of the saccular macula.
Specimen 4E: embryonic day 14.5 (more )
Note: Basal cochlea. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: cochlear duct Present Regionally restricted 4E Expression in the prosensory region of the cochlear duct/organ of Corti.
Specimen 4F: embryonic day 14.5 (more )
Note: Apical cochlea. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS22: cochlear duct Present Regionally restricted 4F Expression in the prosensory region of the cochlear duct/organ of Corti.
Specimen 5A: embryonic day 16.5 (more )
Note: Apical end of cochlear duct. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: cochlear duct Present Regionally restricted 5A Expression in all sensory epithelia in the organ of Corti.
Specimen 5B: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: cochlear duct Present Regionally restricted 5B Expression in all sensory epithelia in the organ of Corti.
Specimen 5C: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: cochlear duct Present Regionally restricted 5C Expression in all sensory epithelia in the organ of Corti.
Specimen 5D: embryonic day 16.5 (more )
Note: Basal end of cochlear duct. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: cochlear duct Present Regionally restricted 5D Expression in all sensory epithelia in the organ of Corti.
Specimen 5E: embryonic day 16.5 (more )
Note: Apical end of cochleovestibular ganglion. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: vestibulo-cochlear ganglion Present Regionally restricted 5E Expression in some cells in the cochleovestibular ganglion.
TS24: cochlear ganglion Present 5E Expression in the spiral ganglion.
Specimen 5F: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: vestibulo-cochlear ganglion Present Regionally restricted 5F Expression in some cells in the cochleovestibular ganglion.
TS24: cochlear ganglion Present 5F Expression in the spiral ganglion.
Specimen 5G: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: vestibulo-cochlear ganglion Present Regionally restricted 5G Expression in some cells in the cochleovestibular ganglion.
TS24: cochlear ganglion Present 5G Expression in the spiral ganglion.
Specimen 5H: embryonic day 16.5 (more )
Note: Basal end of cochleovestibular ganglion. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: vestibulo-cochlear ganglion Present Regionally restricted 5H Expression in some cells in the cochleovestibular ganglion.
TS24: cochlear ganglion Present 5H Expression in the spiral ganglion.
Specimen 5I: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: saccule Present Regionally restricted 5I Expression in all vestibular sensory epithelia in sacullar macula.
Specimen 5J: embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: utricle Present Regionally restricted 5J Expression in all vestibular sensory epithelia in utricular macula.
Specimen 5K,K": embryonic day 16.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS24: semicircular canal Present Regionally restricted 5K" , 5K Expression in all vestibular sensory epithelia in anterior and lateral crista.
Specimen 6A: embryonic day 18.5 (more )
Note: Apical end of cochlear duct. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 6A Expression in all sensory epithelia in the organ of Corti.
Specimen 6B: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 6B Expression in all sensory epithelia in the organ of Corti.
Specimen 6C: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 6C Expression in all sensory epithelia in the organ of Corti.
Specimen 6D: embryonic day 18.5 (more )
Note: Basal end of cochlear duct. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 6D Expression in all sensory epithelia in the organ of Corti.
Specimen 6E: embryonic day 18.5 (more )
Note: Apical end of cochlear duct. Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear ganglion Present Regionally restricted 6E Dispersed expression in the spiral ganglion, but in discretely positive cells of non-neuronal identity.
Specimen 6F: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: cochlear ganglion Present Regionally restricted 6F Dispersed expression in the spiral ganglion, but in discretely positive cells of non-neuronal identity.
Specimen 6I: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: vestibular component epithelium Present Regionally restricted 6I Expression in all sensory epithelia in the vestibular organs.
Specimen 6J: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: vestibular component epithelium Present Regionally restricted 6J Expression in all sensory epithelia in the vestibular organs.
Specimen 6K: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: vestibular component epithelium Present Regionally restricted 6K Expression in all sensory epithelia in the vestibular organs.
Specimen 6L: embryonic day 18.5 (more )
Note: Double labeled: green - Sox2; red - Sox9 (assay MGI:5439829).
Structure Level Pattern Image Note
TS26: vestibular component epithelium Present Regionally restricted 6L Expression in all sensory epithelia in the vestibular organs.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory