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Phenotypes Associated with This Genotype
Genotype
MGI:4868438
Allelic
Composition		 Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm2.1Ifc mutation (2 available); any Ccr2 mutation (43 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )
• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis compared with similarly treated wild-type mice

hematopoietic system
abnormal leukocyte physiology ( J:166664 )
• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory