Gene Expression Data
Assay Details
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Assay
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Reference:
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J:152838
Fu H, et al., A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:4839348
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Gene symbol:
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Tcf7l2
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Gene name:
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transcription factor 7 like 2, T cell specific, HMG box
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Probe:
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MTF#490
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Probe preparation:
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Antisense RNA
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Assay notes:
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According to the corresponding author, a probe from the Mahoney atlas (cf J:91257) was used in this assay. However, there is more than 1 probe for this gene in that set, and it was not specified which was used to generate this data. It is possible either MGI:3506225 and MGI:4879898 were used to obtain these data.
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Results
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Specimen
Table 1:
embryonic day 13.5
(more  )
Specimen
Table 1:
(close  )
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Genetic Background:
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CD-1
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Age:
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embryonic day 13.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Specimen
Table 2:
postnatal day 0
(more )
Specimen
Table 2:
(close )
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Genetic Background:
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CD-1
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: spinal cord |
Present |
Regionally restricted |
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The expression pattern of this gene is suggestive of a role in glial development; it is also expressed in neurons.
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Specimen
2A:
postnatal day 0
(more )
Note: Double labeled: green - Tcf7l2; red - Olig2 (assay MGI:4839209).
Specimen
2A:
(close )
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Genetic Background:
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CD-1
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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Note:
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Double labeled: green - Tcf7l2; red - Olig2 (assay MGI:4839209).
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Specimen
3A - left:
embryonic day 18.5
(more )
Specimen
3A - left:
(close )
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Genetic Background:
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involves: 129S4/SvJae
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Present |
Single cells |
3A Tcf4 Wt
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Expression is present in oligodendrocyte-related cells.
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Specimen
3A - right:
(close )
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Genetic Background:
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involves: 129S4/SvJae
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Mutant Allele(s):
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Olig2tm1Rth/Olig2tm1Rth
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Specimen
4 - WT:
embryonic day 18.5
(more )
Specimen
4 - WT:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Present |
Single cells |
4_WT
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Expression is present in oligodendrocyte-related cells.
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Specimen
4 Nkx2.2-/-:
(close )
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Genetic Background:
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involves: 129X1/SvJ
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Mutant Allele(s):
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Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Ambiguous |
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4_Nkx2.2-/-
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Expression is ablated or attenuated in the mutant compared to wild type.
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Specimen
Not shown:
(close )
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Genetic Background:
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involves: 129X1/SvJ
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Mutant Allele(s):
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Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
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Age:
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postnatal day 5
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Sex:
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Not Specified
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Type:
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section
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Specimen
4 Sox10-/-:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Sox10tm1Weg/Sox10tm1Weg
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Ambiguous |
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4_Sox10-/-
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Expression is ablated or attenuated in the mutant compared to wild type.
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Specimen
4 Olig1-/-:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
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Olig1tm1And/Olig1tm1And
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Ambiguous |
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4_Olig1-/-
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Expression is ablated or attenuated in the mutant compared to wild type.
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Specimen
Not shown:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
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Olig1tm1And/Olig1tm1And
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Age:
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postnatal day 5
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Sex:
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Not Specified
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Type:
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section
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Specimen
4 Nkx6.1-/-:
(close )
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Genetic Background:
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involves: 129
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Mutant Allele(s):
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Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
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Age:
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embryonic day 18.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: spinal cord |
Ambiguous |
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4_Nkx6.1-/-
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Expression is ablated or attenuated in the mutant compared to wild type.
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Analysis Tools