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Phenotypes Associated with This Genotype
Genotype
MGI:4835781
Allelic
Composition		 Tg(SOD1*G93A)1Gur/0
Wlds/+
Genetic
Background		 involves: C57BL/6J * C57BL/6Ola * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G93A)1Gur mutation (4 available)
Wlds mutation (1 available); any Wld mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:105092 )
• prolonged survival (141.98.9 vs. 131.13.7 days), compare with Tg(SOD1*G93A)1Gur mice
• female mice survive longer than the male (145.48.2 vs. 137.67.9 days)

nervous system
slow Wallerian degeneration ( J:105092 )
• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes
abnormal motor neuron innervation pattern ( J:105092 )
• delayed denervation at the neuromuscular junction
• more axons and innervated neuromuscular junctions in nerve roots than Tg(SOD1*G93A)1Gur mutants at day 80
decreased motor neuron number ( J:105092 )
• similar levels of ventral root axon loss to that seen in Tg(SOD1*G93A)1Gur mice
decreased sensory neuron number ( J:105092 )
• similar levels of dorsal root axon loss to that seen in Tg(SOD1*G93A)1Gur mice

homeostasis/metabolism
slow Wallerian degeneration ( J:105092 )
• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory