Analysis Tools
hematopoietic system
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• at 5 months, there are no significant differences in most leukocyte subsets (NK-cells, monocytes/macrophages, and neutrophils) compared to controls
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• significantly enlarged compared to Apoe-null, Fas-heterozygous mice or Apoe-wt, Fas-homozygous mice at 5 months
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• numbers of circulating cells are significantly reduced
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• numbers of circulating cells are significantly reduced comparted to Apoe-wt, Fas-homozygous mice at 5 months
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• serum levels of IgG are significantly higher than in Apoe-null and Apoe-null, Fas-heterozygous mice at 6 weeks and at 5 months
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growth/size/body
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• significantly enlarged compared to Apoe-null, Fas-heterozygous mice or Apoe-wt, Fas-homozygous mice at 5 months
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immune system
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• significantly enlarged compared to Apoe-null, Fas-heterozygous mice or Apoe-wt, Fas-homozygous mice at 5 months
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• numbers of circulating cells are significantly reduced
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• numbers of circulating cells are significantly reduced comparted to Apoe-wt, Fas-homozygous mice at 5 months
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• serum levels of IgG are significantly higher than in Apoe-null and Apoe-null, Fas-heterozygous mice at 6 weeks and at 5 months
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• serum antibodies against oxidized phospholipid (OxPL) are decreased compared to Apoe-wt, Fas-homozygous and Apoe-null, Fas-wt controls
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• levels of IgG anti-cardiolipin antibodies are increased at 5 months relative to controls
• levels of IgG anti-POVPC and anti-PGPC autoantibodies are significantly higher than in controls at 5 months; IgM anti-POVPC levels are increased also
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• serum levels of IgG anti-dsDNA antibodies are significantly higher than in Apoe-null, Fas-wt controls and Apoe-null, Fas-heterozygous mice at 6 weeks and at 5 months
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• renal damage is observed, with IgG and C3 deposits present in the mesangium and peripheral capillary loops
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renal/urinary system
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• at 5 months, renal sections show an increase in apoptotic cells
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• increased apoptotic cells are seen in renal tubules at 5 months
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• proteinuria is increased compared to Fas-homozygous controls; proteinuria is not evident at 1 month of age
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• renal damage is observed, with IgG and C3 deposits present in the mesangium and peripheral capillary loops
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• proliferation of glomerular cells and lobule formation are observed
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• IgG and C3 deposits present in the mesangium and peripheral capillary loops
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• glomerular tuft areas are enlarged compared to controls
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cardiovascular system
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• IgG deposition in thickened aortic intimas is seen at 5 months, but is not observed in controls; neglible complement C3 deposition is observed in double homozygotes
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• increased lesion area at aortic valves in mice on a normal chow diet compared to Apoe-null, Fas-wt controls
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• increase in apoptotic cells in vessel walls of heart (in vascular lesions) is observed at 5 months relative to controls
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skeleton
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• all limbs of female mutants have lower bone mineral densities (BMD) than male mutants at 5 months of age; ostopenia is similar to Apoe-wt, Fas-null mice at 5 months
• femoral BMD is lower in females than controls at 5 months and 9 months; vertebrae BMD shows a similar trend at 5 months and is lower at 9 months
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• at 5 months, vertebrae BMD trends to lower values than controls; at 9 months, BMD is significantly lower
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• femoral BMD in females is lower than in Apoe-null, Fas-wt controls at 5 months and at 9 months
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• at 9 months, a progressive decrease in trabecular bones (BV/TV, connectivity density, trabecular number, trabecular thickness) is observed in females compared to female Apoe-null, Fas-wt controls
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homeostasis/metabolism
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• total serum cholesterol and unesterified cholesterol levels are lower than Apoe-null, Fas-wt controls
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• proteinuria is increased compared to Fas-homozygous controls; proteinuria is not evident at 1 month of age
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cellular
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• at 5 months, renal sections show an increase in apoptotic cells
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• increased apoptotic cells are seen in renal tubules at 5 months
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endocrine/exocrine glands
