Phenotypes for Rag2 MGI:3617415 MGI Mouse

decreased double-negative T cell number ( J:81133 , J:91542 )

• thymus contains few CD44+,CD25-,CD117++ double negative (DN1) cells and CD44+,CD25+ double negative (DN2) cells, representing 7.5% of that in a control mouse (J:81133)

• the number of DN1 and DN2 cells is decreased (J:91542)

• the population of DN1 cells remaining is enriched for proliferating CD117⁺ cells (J:91542)

increased double-negative T cell number ( J:91542 )

• the number of DN3 cells is increased 2 fold

arrested T cell differentiation ( J:91542 )

• a complete block in T cell development at the double negative 3 stage is seen

abnormal B cell morphology ( J:81133 )

• proportion of CD19+, B220+ B cells in the neonatal thymus is extremely low

decreased susceptibility to type IV hypersensitivity reaction ( J:165513 )

• contact hypersensitivity is abolished compared to in wild-type mice

decreased susceptibility to parasitic infection ( J:64283 )

• mice show no sign of lesion development for up to 12 to 14 weeks after infection; after 20 weeks, all lesions remain small

• mice reconstituted with 1x10 ⁷ CD4+ T cells develop smaller lesions containing 100-fold less parasites than wild-type or mutants reconstituted with 1.5x10 ⁷ CD4+ T cells

abnormal intestinal mucosa morphology ( J:64232 )

• when given 10-20 mg/kg indomethacin, mice develop small nonhemorrhagic lesions in the jejunum, similar to controls in severity

abnormal stomach mucosa morphology ( J:64232 )

• when given 10-20 mg/kg indomethacin, mice develop extensive hemorrhagic lesions of the gastric mucosa, similar to controls in severity